【Abstract】Objective　To explore the common causes of acute poisoning in children and the effects of blood purification(BP) . Methods To summarize the cause and therapeutic method and prognosis of 45 cases acute poisoning in children. Results 45 cases of acute poisoning include male 25 cases and female 20 cases, average age was 5.7 years. 10 cases tetramine poisoning were cured with hemoperfusion 3-7 times,8 cases to take a turn for the better,2 cases gave up. 7 cases mushroom poisoning, 4 were treated with combined blood purification and 3 plasmapheresis ,one died,3 turu better,3 gave up.6 cases paraquat poisoning were treated with hemoperfusion,one died,one gave up,4got better. One methomyl poisoning were died.Other 21 cases were treated with hemodialysis and/or hemoperfusion ,all got better or cured. Conclusion Preschool Child was the predilection age of acute poisoning. Poisons was a great variety, tetramine、 mushroom and paraquat were at most. The choose of BP methods should based on the kind of poisons and the condition of patients.The patients who had multiple organs injury should be treated with combined BP methods.