中国血液净化

›› 2002, Vol. 1 ›› Issue (10): 22-24.

• 论著 • 上一篇    下一篇

腹膜透析患者不同腹膜转运类型与炎症反应、营养不良相关关系的研究

吴杏 叶任高 汪涛 高 阳 程慧虹 彭文兴 杨念生 余学清   

  1. 510080 广州，中山大学附属第一医院肾内科，教育部肾脏病临床研究重点试验室，广东省肾脏病重点实验室〔吴 杏(现心内科)，叶任高，汪 涛(现北京大学第一医院)，高 阳，程慧虹，彭文兴，杨念生，余学清〕
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2002-10-19 发布日期:2002-10-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2002-10-19 Published:2002-10-19

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摘要： 【摘要】目的 了解腹膜透析患者腹膜转运类型与炎症反应、营养不良的相关关系。方法 对46例腹膜透析患者行腹膜平衡试验（PET），根据PET结果将腹膜转运功能分为高转运（H）、高于平均(HA)、低于平均(LA)和低转运(L)四型。检查血TNF-α、IL-6以及白蛋白水平，并用主观整体评估（SGA）法评估患者的营养状态。结果 TNF-α水平高转运与低转运相比，差异有显著性(P<0.05)；而白蛋白高转运与低转运相比，差异也有显著性(P<0.05)；IL-6则无显著性差异。根据SGA标准，H营养不良的发生率较L显著增高 (P<0.05)。结论 腹膜通透性高的患者其炎症反应和营养不良的发生率高，说明高通透性的腹膜转运类型是造成炎症反应、营养不良的主要原因。

关键词: 腹膜转运类型, 营养不良, 炎症反应

Abstract:

【Abstract】Objective To investigate the relationship between increased peritoneal transport rate and inflammation, malnutrition. Methods 46 CAPD patients were included in the study. The peritoneal transport function was divided into high transportation, high average, low average and low transportation according to the result of PET. Plasma TNF-α、IL-6 and albumin were tested by biochemical instruments. Their nutritional status were also measured using subjective global assessment (SGA). Results There were 5 cases of low transportation(L), 13 cases of low average (LA), 20 cases of high average(HA) and 8 cases of high transportation type(H) according to PET results. The TNF-α was significantly higher and albumin level was significantly lower in high transport rate patients(P<0.05), while IL-6 was no significantly difference. According to SGA, there was much more malnutrition in high transport rate patients than that in low transport rate(P<0.05). conclusion The incidence of inflammation and malnutrition was higher in the high transport patients. It is suggested high transport rate may lead to inflammation, malnutrition.

Key words: Malnutrition, Inflammation