中国血液净化

›› 2002, Vol. 1 ›› Issue (11): 7-9.

• 论著 • 上一篇    下一篇

连续性静-静脉血液滤过治疗对血液中TNF-α、IL-1、IL-6浓度的影响

沈文清 梁波 麦慈光 李玉儿   

  1. 510150 广东，广州市第二人民医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2002-11-19 发布日期:2002-11-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2002-11-19 Published:2002-11-19

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摘要： 【摘要】目的 探讨连续性静-静脉血液滤过治疗(CVVH)对外周血中肿瘤坏死因子（TNF-α）,白介素-1(IL-1),白介素-6(IL-6)浓度的影响。方法 30 例肾功能不全患者行CVVH,血滤器采用AV600 (聚砜膜, 1.4m2)，治疗前、治疗2h、6h、8h、结束时取血和滤液采用ELISA法测定 TNF-α、 IL-1、 IL-6浓度。 结果 CVVH 过程中血液 TNF-α、 IL-1、 IL-6 浓度缓慢降低， 于 6h 达到最低点， 与治疗前对比差异显著（P < 0.05）。8h 后血液中 TNF-α、 IL-1、 IL-6 浓度逐渐上升。 治疗结束后浓度回升至接近治疗前水平（P > 0.05），滤液中始终未检测到上述因子。结论 CVVH使用聚砜膜滤过器时对血中TNF-α、IL-1、IL-6有清除作用，此种作用于CVVH治疗6小时后消失，其消除方式可能是吸附。

关键词: 连续性静-静脉血液滤过, 细胞因子

Abstract: 【Abstract】Objective To detect serum concentrations of tumor necrotic factor(TNF-а), interleukin-1 (IL-1), interleukin-6 (IL-6) during continuous veno-venous hemofiltration therapy(CVVH) methodology. Methods Thirty patients treated with CVVH，AV600 hemofilter (Polysulfone,1.4m2) was used, Blood and ultrafiltration fluid was sampled before and 2, 6, 8 hours in the process of CVVH. Results During CVVH procedure, TNF-α, IL-1 and IL-6 levels were decreased progressively, got to the lowest at 6 hours,which was significantly lower than 0 hour。After 8 hours, TNF-α, IL-1 and IL-6 levels increase slowly, and none of the three mediators could be detected in the ultrafiltration fluid. Conclution Serum TNF-α, IL-1 and IL-6 got to the nadir at 6 hours in the process of CVVH with polysulfone hemofilter and the clearing of these mediators may be mainly through absorption but not filtration.

Key words: Cytokine