中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (01): 42-44.doi: 10.3969/j.issn.1671-4091.2013.01.00

• 基础研究 • 上一篇    下一篇

活性炭与树脂对尿毒症患者MMS、PTH毒素的体外吸附研究

张文1,王占仁2,黄菊2,田华2,李春茵2   

  1. 1. 重庆希尔康血液净化器材研发有限公司
    2.
  • 收稿日期:2012-06-04 修回日期:2012-07-09 出版日期:2013-01-12 发布日期:2013-01-04
  • 通讯作者: 张文 E-mail:zwenedu@sina.com
  • 基金资助:
    科技部创新基金10C26215115016;中科级.863

Studies on the Adsorption of Middle Molecular Substances and Parathyroid Hormone from Uremic Patients in Vitro with Activated Carbon and Resin

  • Received:2012-06-04 Revised:2012-07-09 Online:2013-01-12 Published:2013-01-04

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摘要： 目的：分析探讨活性炭和树脂对尿毒症患者体内的中分子物质总量（MMS）及甲状旁腺素（PTH）的清除性能差异。方法：取维持性透析患者的血液，随机分为四组，分别用AC活性炭、MR1、MR2、MR3树脂四种吸附剂进行体外吸附，检测吸附前后血液中的MMS和 PTH，结合吸附剂的孔结构检测，分析活性炭与树脂对MMS、PTH的清除性能差异。结果：同组内吸附前后比较，四组血样的MMS、PTH水平差异均有统计学意义(P<0.05)。对MMS清除水平，AC组最高，且与MR1组差异有统计学意义(P<0.05)，3种树脂间MMS清除水平差异无统计学意义。对PTH清除水平MR1＞MR2＞MR3＞AC，四组差异均有统计学意义(P<0.05)。结论：活性炭由于孔径分布范围广，对中分子物质总量清除更有利；大孔吸附树脂具有较为集中的孔径分布，对以PTH为目标的单一中分子毒素清除更有利。

关键词: 活性炭, 大孔吸附树脂, 中分子物质, 甲状旁腺素

Abstract: Objective To explore middle molecular substances (MMS) and parathyroid hormone (PTH) removal performance differences on uremic patients of activated carbon and several resin adsorbent. Methods Maintenance hemodialysis patients’ blood were randomly divided into four groups，respectively for AC（activated carbon）、MR1、MR2、MR3（resin）by adsorption in vitro test. Detect blood MMS and PTH before and after adsorption，combined with the sorbent pore structure，to analyze MMS and PTH removal performance differences of activated carbon and resin. Results Within the same group the comparison of before and after adsorption，four groups of blood MMS，PTH level difference has statistics significance(P MR2> MR3 > AC，four group difference has statistics significance (P<0.05). Conclusions Due to wider pore size distribution range，activated carbon is more favorable on removing the middle molecule substances；resin having relatively centralized pore size distribution，removal for the single molecule toxins such as PTH is more favorable.

Key words: Activated carbon, Macroporous adsorption resin, Middle molecular substances, Parathyroid hormone

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