中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (02): 66-69.doi: 10.3969/j.issn.1671-4091.2013.02.00

• 临床研究 • 上一篇    下一篇

慢性肾脏病不同分期患者认知功能水平的研究

魏媛媛1,程文荣2,梁志锋3,马迎春2,张莉1,祁长凤3,刘松怀3   

  1. 1. 中国康复研究中心北京博爱医院肾内科
    2. 中国康复研究中心北京博爱医院
    3. 中国康复研究中心北京博爱医院心理科
  • 收稿日期:2012-07-16 修回日期:2012-09-17 出版日期:2013-02-12 发布日期:2013-02-12
  • 通讯作者: 马迎春 E-mail:mych323@163.com
  • 基金资助:
    中央级公益性科研院所基本科研业务费专项资金（2010CZ-3）

Cognitive function in patients with different stages of chronic kidney disease

  • Received:2012-07-16 Revised:2012-09-17 Online:2013-02-12 Published:2013-02-12

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摘要： 目的：探讨慢性肾脏病（chronic kidney disease，CKD）不同分期患者认知功能水平的变化。方法: 入选2010年5月至2012年4月在北京博爱医院肾内科就诊的CKD患者，根据基于肌酐的肾小球滤过率（GFR）评估公式估测的GFR（eGFR）水平将患者分为CKD1~2期组、CKD3~4期组、CKD5期组，其中CKD5期组又根据透析与否分为CKD5期非透析组、CKD5期透析组。应用中国修订韦氏成人智力量表（WAIS-RC）进行认知功能水平的评估。采用单因素方差分析法对CKD不同分期患者的认知功能水平进行比较。结果：共入选103例CKD患者，包括CKD1~2期31例，平均年龄（54.77±12.70）岁；CKD3~4期25例，平均年龄（62.24±14.36）岁；CKD5期非透析组10例，平均年龄（60.03±12.10）岁；CKD5期透析组37例，平均年龄（65.00±14.41）岁。随着eGFR的下降，CKD不同分期患者的认知功能水平呈现部分下降的趋势，四组之间在总智商、语言智商、操作智商方面尚未达到统计学差异（P > 0.05）。结论：CKD不同分期的患者，随着eGFR的下降，患者的认知功能有一定程度的下降趋势。

关键词: 慢性肾脏病, 认知功能, 中国修订韦氏成人智力量表

Abstract: Objective To evaluate the cognitive function in patients with different stages of chronic kidney disease (CKD). Methods 103 CKD patients from nephrology department, China Rehabilitation Research Center, Beijing Boai Hospital were enrolled in this study. They were divided into four groups according to eGFR, including CKD1~2 stages group, CKD3~4 stages group, CKD 5 stage non-dialysis group and CKD 5 stage dialysis group. Cognitive function was evaluated by Wechsler Adult Intelligence Scale-Revised by China. Cognitive function in patients with different stages of CKD was compared by using the statistical analysis of one-way ANOVA. Results 103 CKD patients were enrolled. There were 31 patients in the CKD1~2 stages group, the mean age was 54.77±12.70 years; there were 25 patients in the CKD3~4stages group, the mean age was 62.24±14.36 years; there were 10 patients in the CKD5 stage non-dialysis group, the mean age was 60.03 ±12.10 years; there were 37 patients in the CKD5 stage dialysis group, the mean age was 65.00 ±14.41 years; there was a partly decline tendency in cognitive function with eGFR declined. The differences were no statistic significant among the four groups in Full scale Intelligence quotient, Verbal Intelligence quotient and Performance Intelligence quotient（P > 0.05）. Conclusion With the decreasing of eGFR, there was a partly decline tendency in cognitive function in different stages of CKD.

Key words: chronic kidney disease, cognitive function, Wechsler Adult Intelligence Scale-Revised by China

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