中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (04): 195-198.doi: 10.3969/j.issn.1671-4091.2013.04.00

• 临床研究 • 上一篇    下一篇

全段甲状旁腺激素水平对维持性血液透析患者临床指标影响及相关因素分析

刘蔓莉1,皮婧静2,崔路可1,杨斌1,龚蓉3,程弓1   

  1. 1. 成都市第三人民医院肾脏科
    2. 广州中山大学附属第二医院肾科
    3. 成都，1成都市三医院肾内科
  • 收稿日期:2012-11-06 修回日期:2013-02-04 出版日期:2013-04-12 发布日期:2013-07-01
  • 通讯作者: 刘蔓莉 E-mail:lium0624@sina.com

Analysis of biochemical variables under the influence of serum intact parathyroid hormone level and other associated factors of patients undergoing maintenance hemodialysi

  • Received:2012-11-06 Revised:2013-02-04 Online:2013-04-12 Published:2013-07-01

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摘要： 【摘要】目的 探讨不同全段甲状旁腺激素（iPTH）水平对慢性肾脏病维持性血液透析（HD）患者临床指标的影响，并进行相关因素分析。方法 选取HD患者共93例，测定iPTH及血生化指标，根据血iPTH水平分为A组iPTH 300 ng/L，比较三组年龄、糖尿病患病率、透析龄、体质量、体重指数及血生化等临床指标，采用多元线性回归分析血iPTH与年龄、性别、糖尿病、透析龄、血校正钙、血磷、血碱性磷酸酶的相关性。结果 B、C组肌酐和血磷水平较均A组显著升高（P<0.05）；C组透析龄、血校正钙、血碱性磷酸酶水平较A、B组显著升高（P <0.05）；B组透析龄、血清白蛋白较A组有显著增加（P <0.05）；A组糖尿病人患病率最高，B组和C组依次减少，差异有统计学意义（P=0.003）。多元线性回归分析表明，iPTH的平方根即 Sqrt（iPTH）与透析龄（回归系数0.102）及血磷（回归系数3.077）成正相关，与糖尿病（回归系数-1.294）成负相关。结论 全段甲状旁腺激素水平可影响慢性肾脏病维持性血液透析患者的预后；iPTH与透析龄、血磷呈正相关，与糖尿病呈负相关。 【关键词】慢性肾脏病；血液透析；全段甲状旁腺激素

关键词: 【关键词】慢性肾脏病, 血液透析, 全段甲状旁腺激素

Abstract: 【Abstract】Objective To investigate and analyze the biochemical variables under the influence of different levels of serum intact parathyroid hormone and other associated factors of patients undergoing maintenance hemodialysis. Methods 93 CKD patients undergoing maintenance HD were divided into 3 groups according to their serum iPTH level (group A 300 ng/L) Compare the age, prevalence of diabetes, duration on dialysis, body weight, BMI and other serum biochemical variables of patients in 3 groups. The relation between age, gender, diabetes mellitus, duration on dialysis, serum calcium (Ca), phosphorus (P), alkaline phosphates (ALP) were examined by multiple linear regression analysis. Results The serum creatinine and P were significantly higher in group B and C than those in group A (P<0.05). In group C, duration on dialysis, serum Ca and ALP were remarkably higher than those in group A and B (P <0.05). The duration on dialysis and serum albumin(ALB) in group B were obviously elevated as compared with those in group C(P <0.05). From group A to C, There was a decline of diabetes morbidity (P =0.003). There was a positive correlation between duration on dialysis, serum P and iPTH (b=0.102, b=3.077) while a negative correlation between diabetes mellitus and iPTH(b =-1.294).Conclusions the prognoses of patients on maintenance hemodialysis were under the influence of iPTH level. iPTH level was positively related with duration on dialysis and serum P, while it was negatively related with diabetes. [Key words] Chronic kidney disease; Hemodialysis; Intact parathyroid hormone

Key words: [Key words] Chronic kidney disease, Hemodialysis, Intact parathyroid hormone