中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (06): 305-308.doi: 10.3969/j.issn.1671-4091.2013.06.00

• 临床研究 • 上一篇    下一篇

血液透析患者成纤维细胞生长因子23与左室肥厚的相关性研究

徐丰博1,刘惠兰2   

  1. 首都医科大学附属复兴医院肾内科
  • 收稿日期:2012-10-29 修回日期:2013-03-28 出版日期:2013-06-12 发布日期:2013-07-01
  • 通讯作者: 刘惠兰 liuhl2945@163.com E-mail:liuhl2945@163.com

The Relationship Between Serum Level of Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Dialysis Patients

  • Received:2012-10-29 Revised:2013-03-28 Online:2013-06-12 Published:2013-07-01

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摘要： 目的 观察维持性血液透析患者血中成纤维细胞生长因子23（FGF23）水平，探讨维持性血液透析患者(MHD)FGF23的水平及其与左室肥厚之间的关系。方法 选取稳定MHD患者40例，健康对照20人。应用酶联免疫分析法测定血清FGF23和1，25二羟活性维生素D3（1,25-(OH)2D3）水平，同时测定血清甲状旁腺激素（PTH）、血钙（Ca2+）、磷（P3-）、碱性磷酸酶（ALP）、白蛋白（ALB）等指标。所有患者进行超声心动检测，根据Devereux公式计算左室质量指数(LVMI)，根据LVMI值将透析患者分为左室肥厚组及非肥厚组。结果 （1）透析患者血清LogPTH、Log FGF23水平显著高于对照组，Log1,25-(OH)2D3水平显著低于对照组，差异有统计学意义。（2）Log FGF23、LogPTH水平在左室肥厚组显著高于非肥厚组。（3）LVMI与Log FGF23、LogALP呈正相关。（4）逐步多元线性回归分析显示，Log FGF23和LogALP是影响左室肥厚的独立影响因素。结论 维持性血液透析患者血清FGF23明显升高，且FGF23升高和左室肥厚密切相关。

关键词: 成纤维细胞生长因子23, 左室肥厚, 甲状旁腺激素

Abstract: To determine the serum level of fibroblast growth factor 23(FGF23) in maintenance hemodialysis(MHD) patients and explore the relationship between FGF23 and ventricular hypertrophy. Methods: Forty MHD patients and twenty people(control group ) whose renal functions were normal were enrolled in this study. Phosphate、calcium、alkaline phosphatase in their serum were determined . The level of FGF23 and 1,25-(OH)2D3 in serum were detected by the method of ELISA.The patients in MHD were divided into LVH group and non-LVH group according as LVMI. Results: (1)The Log FGF23 and LogPTH in MHD group was much higher than control, Log1,25-(OH)2D3 in MHD group was lower than control.(2)The Log FGF23 and Log PTH in LVH group was much higher than non-LVH group .(3)LVMI was positively correlated with Log FGF23 and Log ALP.(4)Multiple linear regression analysis revealed that the level of Log FGF23 and LogALP was the influencing factor of LVH in MHD patients.Conclusion: The serum level of FGF23 in MHD patients is extremely higher, and the elevation of FGF23 is relative to the left ventricular hypertrophy.

Key words: fibroblast growth factor 23, left ventricular hypertrophy, parathyroid hormone