中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (06): 316-319.doi: 10.3969/j.issn.1671-4091.2013.06.00

• 临床研究 • 上一篇    下一篇

树脂吸附对维持性血液透析难治性高血压患者肾素-血管紧张素-醛固酮系统的影响

徐玉祥1,周青溢1,孙巨军1,肖鹏1,贺晓雯1,张九芝1,范丽1,杨少伟1,李静然2   

  1. 1. 西电集团医院
    2. 珠海健帆生物科技股份有限公司
  • 收稿日期:2012-08-21 修回日期:2013-04-27 出版日期:2013-06-12 发布日期:2013-07-01
  • 通讯作者: 徐玉祥 yx_xu40470@sina.com E-mail:yx_xu40470@sina.com
  • 基金资助:
    陕西省卫生厅科研基金（2010B10）

The effect of resin-absorbed hemoperfusion on the Renin-angiotensin-aldosterone system in hemodialysis patients with resistant hypertension

  • Received:2012-08-21 Revised:2013-04-27 Online:2013-06-12 Published:2013-07-01

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摘要： 目的　探讨树脂吸附对维持性血液透析难治性高血压患者RAS系统的影响。方法　将64例维持性透析患者随机分成两组，每组32人，即HD组：每例患者每周2-3次HD治疗（每次4 h）；HD+HP组：每例患者在HD治疗基础上，每周1次HD+HP治疗（每次2 h HP+2 h HD）。观察治疗前和治疗后8周末血压、血清肾素(PRA)、血管紧张素Ⅱ(ATⅡ)的变化情况。结果 1. HD组治疗前后血压、血清PRA、ATII及PTH水平变化不明显，无统计学差异(P>0.05)；2. HD+HP组治疗后血压、血清PRA、ATⅡ及PTH水平均较治疗前明显下降,且各指标均较HD组治疗后明显下降，差异均有统计学意义(P<0.01)。 结论　树脂吸附联合血液透析较单纯血液透析能明显降低尿毒症维持性血透患者血浆肾素-血管紧张素的水平,可使维持性血液透析难治性高血压患者的血压得到有效控制。

关键词: 血液透析, 血液灌流, 尿毒症, 难治性高血压

Abstract: Objective: To investigate the effect of resin-absorbed hemoperfusion on Renin-angiotensin-aldosterone system in hemodialysis patients with resistant hypertension. Methods: 64 patients in our hospital were randomly divided into 2 groups, each group has 32 cases. Each patient has 2 or 3 times dialysis for a week in the group of HD. And other group of patients received 1 time resin-absorbed hemoperfusion on the basis of conventional dialysis once a week. Observed the changes of blood pressure, renin , angiotensin II and parathyroid hormone before treatment and after 8 weeks treatment. Result: 1. The blood pressure, renin , angiotensin II and parathyroid hormone of the patients were no significant difference compared with before treatment in the group of HD. 2. After 8 weeks treatment, the blood pressure, renin , angiotensin II and parathyroid hormone of the patients in the group of HD+HP were significantly lower than before, and each index were significantly lower than the group of HD at the same tiame. Conclusion: Resin-absorbed hemoperfusion combined with hemodialysis can better control the bloodpressure and effectively reduce the levels of renin and angiotensin II of uraemia patients.

Key words: Hemodialysis, Hemoperfusion, Uremia, Intractable hypertension

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