中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (07): 349-352.doi: 10.3969/j.issn.1671-4091.2013.06.00

• 临床研究 • 上一篇    下一篇

CKD患者各期BMP-2水平变化及其影响因素

胡明亮1,郑智华2,黄莺2   

  1. 1. 深圳市龙岗中心医院
    2. 中山大学附属第一医院肾内科
  • 收稿日期:2013-01-28 修回日期:2013-03-30 出版日期:2013-07-12 发布日期:2013-07-06
  • 通讯作者: 郑智华 E-mail:zhihuazheng@126.com

Plasma bone morphogenetic protein-2 and related influence factors in patients of chronic kidney disease

  • Received:2013-01-28 Revised:2013-03-30 Online:2013-07-12 Published:2013-07-06

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摘要： 目的：探讨CKD1-5期患者血清BMP-2水平变化及其可能的影响因素。方法：收集CKD各期的154例血液样本。测定血清BMP-2水平和常规生化测定肾功能、白蛋白、C-反应蛋白及钙磷代谢等。结果：CKD1～5期各有26、 22、26、20、28例，HD 32例，对照 28例。与正常对照比较，CKD4,CKD5期及HD患者血清BMP-2水平明显升高；血清BMP-2水平在CKD患者下列情况下显著升高：血磷大于1.4mmol/l或钙磷沉积大于55 mg2/dl2；血清白蛋白低于35g/l；C-反应蛋白大于3000μg/l。相关分析结果提示，BMP-2与血磷水平，钙磷乘积，C-反应蛋白，血尿素氮，血肌酐呈显著正相关；与血清白蛋白和肾小球滤过率呈显著负相关。结论：BMP-2在CKD中晚期和血液透析患者血清中明显升高，残存肾功能、钙磷代谢、炎症和白蛋白可能与CKD患者血清BMP-2水平有关。结果提示BMP-2可能介入CKD和血透患者血管钙化的发病过程。

关键词: 骨形态蛋白-2, 慢性肾脏病, 钙磷代谢

Abstract: Objectives: To investigate the level and variation of serum BMP-2, and how the eGFR, calcium-phosphate metabolism, inflammmation, lipids profile and nutrition index affact the production of BMP-2 in different phases of CKD. Methods: 154 patients with different phases of CKD were enrolled by a cross –section design. BMP-2 was measured by Elisa and clinical biochemistry parameters were evaluated at the same time . Results:The total of 154 patients come from 26 patients in CKD1, 22 in CKD2, 26 in CKD3, 20 in CKD4, 28 in pre-dialysis CKD5 and 32 patients who were undergoing maintenance hemodialysis. 28 healthy subjects was served as control. As a result: ① It demonstrated that the level of seru BMP-2 increased significantly in patients of CKD4, 5 and hemodialysis. ② The level of BMP-2 wassiginificant high in those patients such as，plasma phosphate > 1.62mmol/l or Ca × PO4 product > 55 mg2/dl2 ；serum albumin 3000 mg/l. ③BMP-2 level were positively correlated to serum phosphate, calcium phosphate product, CRP, BUN, creatinine and negatively correlated to seru albumin and glomerular filtration rate. Conclusions: The level of seru BMP-2 gradually increased in patients of advanced CKD and hemodialysis.The variation of BMP-2 is associated with renal function, calcium-phosphate metabolism, inflammation and albumin.

Key words: Bone morphogenetic protein 2, Chronic kidney disease, mineral metabolism