关键词: 骨髓瘤肾病, 血清游离轻链, 血液净化

Abstract: 【Abstract】Renal injury is a common complication of hematologic tumor and renal function is closely related to the quality of life and prognosis in these patients. Due to nephrotoxicity of chemotherapy drugs, toxic substances produced by tumors, dehydration and infection complications, the renal injury is irreversible in most patients. However, with the advances of research, better comprehension of the renal injury mechanism and application of various new drugs with low nephrotoxicity, this renal injury is expected to be improved, or to be reversed to normal level in some cases. The improvement of renal function is of great benefit to the prognosis of tumors. Meanwhile, multiple myeloma differs from other hematologic tumors in that it secretes excessive free light chains that bind to the Tamm-Horsfall protein in distal convoluted tubules to form casts, which deposit in kidney resulting in cast nephropathy and renal injury. Recent advances in management indicate that chemotherapy combined with blood purification have a better effect on myeloma nephropathy, even better than the renal injuries in other related hematological diseases.

Key words: Myeloma nephropathy, Serum free light chain, Hemopurification