中国血液净化

›› 2008, Vol. 7 ›› Issue (5): 243-247.

• 论著 • 上一篇    下一篇

低出生体重影响肾小球滤过率的荟萃分析

许 戎 左 力 王海燕   

  1. 北京大学第一医院肾脏内科暨北京大学肾脏病研究所
  • 收稿日期:2008-03-19 修回日期:1900-01-01 出版日期:2008-05-12 发布日期:2008-05-12

Low birth weight influences glomerular filtration rate: a meta analysis

XU Rong, ZUO Li, WANG Hai-yan   

  • Received:2008-03-19 Revised:1900-01-01 Online:2008-05-12 Published:2008-05-12

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摘要：

【摘要】目的 研究比较低出生体重对肾小球滤过率的远期影响。方法 以“birth weight”、“creatinine clearance”、“glomerular filtration rate”、“renal function”对Pubmed所有文献进行检索。按筛选标准共有7篇文献入选。使用Revman4.2进行统计分析。结果 低出生体重者肾小球滤过率较低，约比正常出生体重者降低4ml/min/1.73m2，剔除以儿童为观察对象的研究后，结果仍显示低出生体重者肾小球滤过率较低，约比正常出生体重者降低3～4ml/min/1.73m2。结论 低出生体重者在儿童期以后虽然肾小球滤过率在正常范围，但已比正常出生体重者有降低。

关键词: 低出生体重, 肾小球滤过率, 荟萃分析

Abstract: 【Abstract】 Objective To study the effect of low birth weight on glomerular filtration rate (GFR) in adulthood. Methods We searched the database PubMed for related literature by using the keywords birth weight, creatinine clearance, glomerular filtration rate and renal function. According to our study purposes, 7 clinical study reports were included and analyzed. Revman 4.2 was used for data analysis. Results GFR of individuals with a low birth weight was normal, however, their GFR was 4ml/min/1.73m2 lower than that of those with a normal birth weight. This finding is still evident after we exclude 2 studies measured in childhood. Conclusion GFR of adult individuals with a low birth weight is in the normal range, but is lower than that of those with a normal birth weight.

Key words: Glomerular filtration rate, Meta analysis