中国血液净化

›› 2003, Vol. 2 ›› Issue (4): 205-207.

• 人工肝 • 上一篇    下一篇

综合治疗联合人工肝治疗慢性重型肝炎的临床研究

向德栋 王宇明 毛 青 张绪清   

  1. 400038 重庆，第三军医大学西南医院全军感染病研究所
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-04-19 发布日期:2003-04-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-04-19 Published:2003-04-19

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摘要： 目的 观察人工肝治疗慢性重型肝炎的临床疗效。方法 对60例慢性重型肝炎患者在综合治疗 基础上给予人工肝治疗。结果 60例慢性重型肝炎患者治疗前血清胆红素［(656.7±297.8) μmol/L］，内毒素［(60.2±11.3）ng/L］、肿瘤坏死因子α［（2835.9±810.7）ng/L］、白介素-1β［(2041.9±890.6)ng/L］、白介素-6［(162.5±178.6)ng/L］、凝血酶原活动度为22.2%±10.3%，均有明显的消化症状，经人工肝治疗后，血清胆红素、内毒素、肿瘤坏死因子α下降［(436.1±255.7)μmol/L，(30.8±10.6)ng/L， P<0.01; (2462.1±920.7) ng/L， P<0.05］，但对白介素 -1β［(2031.5±836.8)ng/L, P>0.05］及白介素-6［(141.7±154.7) ng/L, P>0.05］无明显下降。凝血酶原活动度上升［(38.1%±13.2%)， P<0.01］，部分患者消化道症状明显改善，人工肝治疗慢性重型肝炎治愈及好转率为38.3%，降低了慢性重型肝炎的病死率。 结论 人工肝为重型肝炎的治疗提供了有效手段。

关键词: 慢性重型肝炎, 人工肝, 肿瘤坏死因子α, 内毒素

Abstract:
Objective To study the therapeutic effects of artificial liver on patients with chronic severe hepatitis. Method Sixty patients with chronic severe hepatitis received a combined therapy artificial liver. Results After artificial liver treatment, serum bilirubin,endotoxin (ET), Tumor necrosis factor alpha (TNFα) in patients with chronic severe hepatitis obviously reduced and prothrombin activity (PTA) increased, symptoms of digestive tract in some patients with chronic severe hepatitis were improved. But it could not reduce Interleukin-1 bata (IL-1β)and Interleukin-6(IL-6).The cure and improved rate of these patients was 38.3% by the treatment of artificial liver. This treatment reduced mortality rate of these chronic severe hepatitis patients. Conclusion Artificial liver is an effective therapy for chronic severe hepatitis.

Key words: Artificial liver, Tumour necrosis factor alpha, Endotoxin