中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (02): 145-148.doi: 10.3969/j.issn.1671-4091.2025.02.010

• 综述 • 上一篇    下一篇

三发性甲状旁腺功能亢进症研究进展

王秀川   王兆军   

  1. 250031 济南，济南市第四人民医院1肾内科 2药学部
  • 收稿日期:2024-05-16 修回日期:2024-11-16 出版日期:2025-02-12 发布日期:2025-02-12
  • 通讯作者: 王兆军 E-mail:13668800211@163.com

Research progress in tertiary hyperparathyroidism

WANG Xiu-chuan, WANG Zhao-jun   

  1. Department of Nephrology,  2Department of  Pharmacy Jinan Fourth People's Hospital, Jinan 250031, China
  • Received:2024-05-16 Revised:2024-11-16 Online:2025-02-12 Published:2025-02-12
  • Contact: 250031 济南，济南市第四人民医院2药学部 E-mail:13668800211@163.com

摘要： 三发性甲状旁腺功能亢进症(tertiary hyperparathyroidism，THPT)是在长期继发性甲状旁腺功能亢进症(secondary hyperparathyroidism,SHPT)的基础上发展而来，其特征是甲状旁腺激素(PTH)自主分泌，血清钙水平升高，通常发生在肾移植后。THPT会增加骨折的风险，促进冠状动脉钙化，并是影响肾移植受者的重要因素；手术是THPT的首选治疗方法，但部分患者因未能及时识别并诊断该病而错过了最佳手术时机。为提高对THPT的认识，本文综述了THPT的发病机制、临床表现、影像学特点、诊断和治疗方面的最新进展。

关键词: 三发性甲状旁腺功能亢进, 甲状旁腺激素, 肾移植, 甲状旁腺切除术

Abstract: Tertiary hyperparathyroidism (THPT) develops on the basis of long-standing secondary hyperparathyroidism (SHPT), characterized by autonomous secretion of parathyroid hormone (PTH) and elevated serum calcium level, and typically happens after kidney transplantation. THPT can lead to the risks of bone fracture and coronary artery calcification, and is an important factor affecting the recipients of renal transplantation. Surgery is the preferable treatment for THPT. However, some patients lose the optimal period of surgical treatment due to delayed diagnose of THPT. This article reviews recent advances in pathogenesis, clinical manifestations, imaging characteristics, diagnosis, and treatment of THPT in order to improve our knowledge about THPT.

Key words: Tertiary hyperparathyroidism, Parathyroid hormone, Renal transplantation, Parathyroidectomy

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