中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (03): 189-192.doi: 10.3969/j.issn.1671-4091.2025.03.004

• 临床研究 • 上一篇    下一篇

HA380联合连续性静脉-静脉血液透析滤过技术在脓毒症休克供体脏器维护中的应用

刘金泉   王淑贤   冯 帅   许传屾   

  1. 266000 青岛，1青岛大学附属医院器官移植中心
  • 收稿日期:2024-05-28 修回日期:2024-12-08 出版日期:2025-03-12 发布日期:2025-03-12
  • 通讯作者: 许传屾 E-mail:xchuanshi@yeah.net

Application of HA380 combined with CVVHDF technology in organ maintenance of septic shock donors

LIU Jin-quan, WANG Shu-xian, FENG Shuai, XU Chuan-shen   

  1. rgan transplant center, The Affiliated Hospital of Qingdao University, Qingdao 266000, China
  • Received:2024-05-28 Revised:2024-12-08 Online:2025-03-12 Published:2025-03-12
  • Contact: 266000 青岛，1青岛大学附属医院器官移植中心 E-mail:xchuanshi@yeah.net

摘要： 目的  探讨血液灌流器HA380进行血液灌流联合连续性静脉-静脉血液透析滤过(continuous veno-venous hemodiafiltration，CVVHDF)技术对于脓毒症休克捐献者肝功能的维护作用，旨在提高脓毒症休克捐献者肝的利用率。 方法  回顾性分析2020年11月─2022年11月青岛大学附属医院33例成功捐献器官的脓毒症休克捐献者临床资料，所有捐献者均接受HA380联合CVVHDF技术进行器官功能维护治疗，观察脓毒症休克捐献者治疗前后炎症反应、肝功能指标的变化。 结果 与治疗前相比，治疗后脓毒症休克捐献者白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、总胆红素(TB)水平均降低(t=12.462、6.252、6.995、3.305、6.360，均P＜0.001)；脓毒症休克捐献者的谷丙转氨酶(ALT)、谷草转氨酶(AST)治疗前后比较无统计学差异(t=0.035、0.930，P=0.972、0.356)。 结论  HA380联合CVVHDF技术用于脓毒症休克捐献者的脏器维护中效果明显，可降低炎症反应，改善供肝质量与脏器功能，一定程度上提升捐献者器官利用率。

关键词: 脓毒症休克, 器官捐献, 血液灌流, 连续性静脉-静脉血液透析滤过, 脏器维护

Abstract: Objective   To explore the maintenance effect of HA380 hemoperfusion combined with continuous veno-venous hemodiafiltration (CVVHDF) on liver function of septic shock donors, in order to improve the utilization rate of liver of septic shock donors. Methods  The clinical data of 33 septic shock donors who successfully donated organs in our hospital from November 2020 to November 2022 were retrospectively analyzed. All of them received HA380 combined with CVVHDF for organ function maintenance treatment, and the changes of inflammatory reaction and liver function indexes of septic shock donors before and after treatment were observed. Results  Compared with before treatment, the levels of white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), interleukin -6 (IL-6) and total bilirubin (TB) of septic shock donors decreased after treatment (t=12.462, 6.252, 6.995, 3.305, 6.360, P＜0.001). There was no significant difference in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) among donors with septic shock before and after treatment (t=0.035,0.930, P=0.972, 0.356).  Conclusion  HA380 combined with CVVHDF technology is effective in organ maintenance of septic shock donors, which can reduce inflammatory reaction, improve the quality of donor liver and organ function, and improve the organ utilization rate of donors to some extent.

Key words: Septic shock, Organ donation, Hemoperfusion, Continuous veno-venous hemodiafiltration, Organ maintenance

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