中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (03): 222-225.doi: 10.3969/j.issn.1671-4091.2025.03.011

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速尿负荷试验：预测急性肾损伤患者肾脏替代治疗时机的潜力

周洁容   侯启亮   王 森   袁子茜   高兴梅   李 斌   

  1. 兰州 730000，1兰州大学第一临床医学院
    兰州 730000，2兰州大学第一医院重症医学科
  • 收稿日期:2024-07-16 修回日期:2024-11-12 出版日期:2025-03-12 发布日期:2025-03-12
  • 通讯作者: 李斌 E-mail:libzhr@lzu.edu.cn
  • 基金资助:

Furosemide loading test: potential to predict the timing of renal replacement therapy in patients with acute kidney injury

ZHOU Jie-rong, HOU Qi-liang, WANG Sen, YUAN Zi-qian, GAO Xing-mei, LI Bin   

  1. The First Clinical Medical School, Lanzhou University, Lanzhou 730000, China; 2Department of Intensive Care Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, China
  • Received:2024-07-16 Revised:2024-11-12 Online:2025-03-12 Published:2025-03-12
  • Contact: 兰州 兰州 730000，1兰州大学第一临床医学院 730000，2兰州大学第一医院重症医学科 E-mail:libzhr@lzu.edu.cn

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摘要： 急性肾损伤(acute kidney injury，AKI)患者何时启动肾脏替代治疗(renal replacement therapy，RRT)，医学界始终未能达成共识。近年来，速尿负荷试验(furosemide loading test，FST)显示出一定的预测潜力。FST阳性者宜早启动，阴性者则可延迟。但FST的应用仍有局限，需优化以提升预测准确性。未来可结合其他生物标志物和临床指标，构建更完善的AKI预测模型，以提供全面指导。

关键词: 急性肾损伤, 肾脏替代治疗, 速尿负荷试验

Abstract: The medical community has never reached a consensus on when to initiate renal replacement therapy (RRT) in patients with acute kidney injury (AKI). In recent years, furosemide loading test (FST) has shown its predictive potential. Early initiation of RRT is desirable in FST-positive patients, while it can be delayed in negative patients. However, the application of FST still has limitations and needs to be optimized to improve its prediction accuracy. In the future, a better AKI prediction model can be constructed by combining other biomarkers and clinical indicators to provide comprehensive guidance for physicians.

Key words: Acute kidney injury, Renal replacement therapy, Furosemide loading test 

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