中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (05): 370-374.doi: 10.3969/j.issn.1671-4091.2025.05.003

• 临床研究 • 上一篇    下一篇

三酰甘油葡萄糖-体质量指数与糖尿病肾病患者血管钙化的关系：1项回顾性队列研究

王玉溪    高宏华    鲁 冰    陈 辉   

  1. 473000 南阳，1南阳市中心医院肾内科
  • 收稿日期:2024-08-12 修回日期:2025-02-04 出版日期:2025-05-12 发布日期:2025-05-12
  • 通讯作者: 高宏华 E-mail:gaohonghua0@163.com

Study on the relationship between triglyceride glucose body mass index and vascular calcification in patients with diabetic nephropathy

WANG Yu-xi, GAO Hong-hua,LU Bing,CHEN Hui   

  1. Department of Nephrology,Nanyang Central Hospital,Nanyang 473000,China
  • Received:2024-08-12 Revised:2025-02-04 Online:2025-05-12 Published:2025-05-12
  • Contact: 473000 南阳，1南阳市中心医院肾内科 E-mail:gaohonghua0@163.com

摘要： 目的  探讨三酰甘油葡萄糖-体质量指数(triglycerides glucose-body mass index，TyG-BMI)与糖尿病肾病(diabetic nephropathy，DN)患者血管钙化的关系。 方法 回顾性收集2020年6月—2024年5月南阳市中心医院收治的DN患者，依据患者入院时TyG-BMI指数将患者分为4组(TyG-BMI Q1、Q2、Q3、Q4)。采用Logistic回归模型分析患者TyG-BMI指数与血管钙化的关系，并进行趋势分析。利用限制性立方样条图(restricted cubic spline diagram，RCS)分析TyG-BMI指数预测DN患者发生血管钙化风险的使用价值。 结果 共纳入424例患者，DN患者血管钙化发生率为30.90%(131/424)；TyG-BMI指数中位数为35.87，TyG-BMI Q1组、Q2组、Q3组、Q4组血管钙化发生率分别为27.36%(29/106)、15.09%(16/106)、33.96%(36/106)、47.17%(50/106)，组间比较差异有统计学意义(χ2=26.633，P＜0.001)。校正全部混杂因素，与Q1组比较，Q3组、Q4组的血管钙化风险分别增加1.893倍(OR=2.893，95% CI：1.485～5.634，P=0.002)、4.022倍(OR=5.022，95% CI：2.610～9.663，P＜0.001)。趋势分析显示：模型校正前后，不同TyG-BMI分组患者血管钙化风险的OR值呈增加趋势(P趋势＜0.001)；RCS分析显示TyG-BMI指数与DN患者血管钙化风险有非线性关联趋势(P非线性=0.011)。 结论 在DN患者中，TyG-BMI是血管钙化的危险因素，当TyG-BMI高于35.87时，血管钙化的风险显著增加。

关键词: 糖尿病肾病, 三酰甘油葡萄糖-体质量指数, 血管钙化

Abstract: Objective  To investigate the relationship between triglyceride glucose body mass index (TyG BMI index) and vascular calcification in patients with diabetic nephropathy (DN).  Method  A retrospective study was conducted among 424 DN patients admitted to our hospital from June 2020 to May 2024. The patients were divided into four groups based on their TyG BMI index at admission (TyG BMI Q1 TyG BMI Q4), and the differences in age, gender, vascular calcification, etc. were compared among the four groups. Logistic regression models were used to analyze the relationship between TyG BMI index and vascular calcification in patients, and conducting trend analysis and stratified analysis. The predictive value of predicting the risk of vascular calcification in DN patients was assessed using restricted cubic spline plot (RCS) analysis of TyG BMI index.  Result  The incidence of vascular calcification in DN patients was 30.90% (131/424). The median TyG-BMI index is 35.87. The incidence of vascular calcification in the TyG BMI Q1, Q2, Q3, and Q4 groups of DN patients was 27.36% (29/106), 15.09% (16/106), 33.96% (36/106) and 47.17% (50/106), respectively, with statistically significant differences (χ2=26.633, P<0.001). When adjusting for all confounding factors, compared with the Q1 group, the risk of vascular calcification increased by 1.893 times in the Q3 group (OR=2.893, 95% CI: 1.485～5.634, P=0.002), and 4.022 times in the Q4 group (OR=5.022, 95% CI:2.610～9.663, P＜0.001). Trend analysis shows that before and after model correction, the OR values of vascular calcification risk in patients with different TyG BMI groups showed an increasing trend (P trend<0.001). RCS analysis showed that there was a nonlinear association between TyG-BMI index and the risk of vascular calcification in DN patients  (Pnonlinearity=0.011).  Conclusion  In patients with DN, TyG-BMI was a risk factor for vascular calcification, and the risk of vascular calcification was significantly higher when TyG-BMI was higher than 35.87.

Key words: Diabetic nephropathy, Triglyceride glucose-body mass index, Vascular calcification

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