目的 探讨维持性血液透析(maintenance hemodialysis,MHD)患者家属心理状况对患者的影响。 方法 入组中国康复研究中心血液透析超过3个月的MHD患者及家属，评估二者心理状态、生活质量等指标的相关性。 结果 患者及其对应家属各入组140例，家属焦虑评分与患者焦虑评分呈正相关 (r=0.190，P=0.025)，与患者健康相关生活质量评分中的症状评分、肾脏病影响评分、肾脏病负担评分、躯体功能评分及心理状态评分呈负相关(r=-0.183、-0.208、-0.189、-0.216、-0.188，P=0.030、0.014、0.026、0.011、0.026)；家属抑郁评分与患者焦虑、抑郁评分呈正相关(r=0.192、0.359，P值分别为0.023、 ＜0.001)，与患者症状评分、肾脏病影响评分、心理状态评分呈负相关(r=-0.173、-0.215、 -0.185，P=0.041、0.011、0.029)；家属无焦虑(n=116)、无抑郁(n=53)时MHD患者的血β2微球蛋白较低(t=-2.364，-2.100，P=0.019、0.038)；家属无抑郁时MHD患者的血白蛋白水平较高(t=2.078，P=0.040)。 结论 家属的心理状态与患者焦虑、抑郁水平、生活质量及血β2微球蛋白水平、血白蛋白水平均相关。
Abstract
Objective To explore the influence of the psychological status of family members on patients undergoing maintenance hemodialysis (MHD). Methods MHD patients who had undergone hemodialysis for more than three months at the China Rehabilitation Research Center and their family members were enrolled. The correlation between their psychological status, quality of life, and other indicators was assessed. Results A total of 140 patients and their corresponding family members were enrolled. Family members' anxiety scores were positively correlated with patients' anxiety scores (r=0.190, P =0.025), and negatively correlated with patients' health-related quality of life subscores, including symptom score, kidney disease impact score, kidney disease burden score, physical function score, and psychological status score (r=−0.183,−0.208, −0.189, −0.216, −0.188; P=0.030, 0.014, 0.026, 0.011, 0.026). Family members' depression scores were positively correlated with patients' anxiety and depression scores (r=0.192, 0.359;P=0.023,<0.001,respectively), and negatively correlated with patients' symptom score, kidney disease impact score, and psychological status score (r =−0.173, −0.215, −0.185; P =0.041, 0.011, 0.029). When family members were free of anxiety (n=116) or depression (n=53), MHD patients had lower serum β2-microglobulin levels (t=−2.364, −2.100; P=0.019, 0.038). When family members were free of depression, MHD patients had higher serum albumin levels (t =2.078, P=0.040). Conclusion The psychological status of family members is correlated with patients' anxiety and depression levels, quality of life, serum β2-microglobulin levels, and serum albumin levels.
关键词
维持性血液透析 /
家属 /
焦虑 /
抑郁
Key words
Maintenance hemodialysis ;Family members /
Anxiety /
Depression
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