中国血液净化

中国血液净化 ›› 2026, Vol. 25 ›› Issue (06): 490-494.doi: 10.3969/j.issn.1671-4091.2026.06.010

• 临床研究 • 上一篇    下一篇

维持性血液透析患者血清骨保护素、血清和糖皮质激素诱导蛋白激酶3、溶质载体家族成员11水平与营养不良-炎症-动脉粥样硬化综合征的关系及联合检测价值

杨 青    郑启刚    冯婷婷   龚正堂    李 欢    杜伶俐   

  1. 448000 荆门，1荆门市人民医院肾内科
  • 收稿日期:2025-08-06 修回日期:2026-01-30 出版日期:2026-06-12 发布日期:2026-06-12
  • 通讯作者: 杜伶俐 E-mail:623372@163.com
  • 基金资助:
    荆门市科学技术研究与开发计划(2023YDKY029)

The relationship between serum serum SGK3, OPG, SLC7A11 and malnutrition - inflammation - atherosclerosis syndrome in maintenance hemodialysis and the value of their joint detection

YANG Qing, ZHENG Qi-gang, FENG Ting-ting, GONG Zheng-tang, LI Huan1, DU Ling-li   

  1. Department of Nephrology, Jingmen People's Hospital, Jingmen 448000, China
  • Received:2025-08-06 Revised:2026-01-30 Online:2026-06-12 Published:2026-06-12
  • Contact: 448000 荆门，1荆门市人民医院肾内科 E-mail:623372@163.com

摘要： 目的  探讨维持性血液透析(maintenance hemodialysis，MHD)患者血清骨保护素(osteoprotegerin，OPG)、血清和糖皮质激素诱导蛋白激酶3(serum and glucocorticoid inducible kinase 3，SGK3)、溶质载体家族7成员11(solute carrier family 7 member 11，SLC7A11)水平与营养不良-炎症-动脉粥样硬化综合征(malnutrition-inflammation-atherosclerosis syndrome，MIAS)的关系及三者联合检测价值。 方法  选取2022年6月─2024年6月荆门市人民医院收治的MHD患者172例，将患者分为MIAS组(55例)、非MIAS组(117例)。应用Lasso回归分析、多因素Logistic回归分析、受试者工作特征(receiver operating characteristic，ROC)曲线进行分析。 结果 Lasso分析共筛选出高敏C反应蛋白(high-sensitivity C reactive protein，hs-CRP)、内膜中层厚度(intimal-medial thickness，IMT)、OPG、SGK3、SLC7A11为MIAS的预测因子。IMT(OR=2.951，95%CI：1.179～7.385，P=0.021)、OPG(OR=3.272，95%CI：1.339～7.998，P=0.009)、SGK3(OR=3.189，95%CI：1.362～7.466，P=0.008)是MHD患者并发的MIAS的危险因素，SLC7A11(OR=0.294，95%CI：0.122～0.706，P=0.006)是保护因素。血清OPG、SGK3、SLC7A11单独及联合预测MHD患者并发的MIAS的AUC为0.839、0.822、0.806、0.940，联合效能较优于较单独检测(Z=4.088、3.558、3.947，均P＜0.001)。 结论  MHD并发MIAS患者血清OPG、SGK3水平升高，SLC7A11水平下降，三者联合检测或可作为预测MHD患者发生MIAS的血清指标。

关键词: 维持性血液透析, 营养不良-炎症-动脉粥样硬化综合征, 骨保护素, 血清和糖皮质激素诱导蛋白激酶3, 溶质载体家族7成员11

Abstract: Objective  To investigate the relationship between serum levels of osteoprotegerin (OPG), serum and glucocorticoid inducible kinase 3 (SGK3), solute carrier family 7 member 11 (SLC7A11) and malnutrition-inflammation-atherosclerosis syndrome (MIAS) in patients undergoing maintenance hemodialysis (MHD), and to evaluate the value of their combined detection.  Methods  A total of 172 MHD patients admitted to Jingmen People's Hospital from June 2022 to June 2024 were enrolled and divided into MIAS group (55 cases) and non-MIAS group (117 cases). The analysis was conducted using Lasso regression, multivariate logistic regression and receiver operating characteristic (ROC) curves.  Results  Lasso analysis identified high-sensitivity C reactive protein (hs-CRP), intimal-medial thickness (IMT), OPG, SGK3, and SLC7A11 as predictors of MIAS. IMT (OR=2.951, 95%CI:1.179～7.385, P=0.021), OPG (OR=3.272, 95% CI:1.339～7.998, P=0.009), and SGK3 (OR = 3.189, 95% CI:1.362～7.466, P=0.008) were risk factors for MIAS in MHD patients, while SLC7A11 (OR = 0.294, 95% CI:0.122～0.706, P=0.006) was a protective factor. The area under the curve (AUC) of serum OPG, SGK3, and SLC7A11 alone and in combination for predicting MIAS in MHD patients was 0.839, 0.822, 0.806, and 0.940, respectively, with the combined efficacy being superior to that of each individual indicator (Z=4.088,3.558,3.947,all P＜0.001).  Conclusion  Serum OPG and SGK3 levels are elevated and SLC7A11 level is decreased in MHD patients with MIAS. The combined detection of these three indicators may serve as a serum biomarker for predicting MIAS in MHD patients.

Key words: Maintenance hemodialysis, Malnutrition-inflammation-atherosclerosis syndrome, Osteoprotegerin, Serum and glucocorticoid inducible kinase 3, Solute carrier family 7 member 11

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