中国血液净化

›› 2006, Vol. 5 ›› Issue (6): 311-312.

• 论著 • 上一篇    下一篇

大剂量维生素C预冲透析器对血液透析患者晚期氧化蛋白产物的影响 　　　　　　　　　　　　　　　

彭侃夫 吴雄飞 王军霞 吴 亿   

  1. 400038 重庆，第三军医大学西南医院肾科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-06-12 发布日期:2006-06-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-06-12 Published:2006-06-12

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摘要： 目的 研究大剂量维生素C预冲透析器对血液透析患者晚期氧化蛋白产物(Advanced oxidation protein products，AOPP)的影响。方法 选择在重庆西南医院住院及门诊接受血液透析患者及同期门诊体检人群160名。分为正常对照组、尿毒症组、常规血液透析组和治疗组，分别检测循环AOPP的水平，差异进行显著性检验。结果 尿毒症患者(未行血液透析)的AOPP水平较正常对照组显著升高，而经过半年血液透析的患者其AOPP水平较未透析患者又明显升高，但透析前经过大剂量维生素C预处理透析器后其AOPP明显下降(P均＜0．01)，差异有统计学意义。结论 大剂量维生素C预冲透析器对血液透析患者AOPP升高有抑制作用。

关键词: 维生素C, 血液透析, AOPP, 透析器

Abstract: Objective To investigate the effect of preconditioning high dose vitamin C for the dialyzer on advanced oxidation protein products(AOPP) in hemodialysis patients. Methods One hundred and sixty adults were randomly selected including in-patients in the nephrology ward and healthy subjects for routine medical examination. The subjects were classified into 4 groups: Normal subjects(NS),uremia (U), hemodialysis (HD) and therapy (T) group. The serum levels of AOPP were measured respectively. Results Serum levels of AOPP were significantly higher in uremia patients compared with healthy controls(P ＜0.01),while higher in HD patients than in uremia patients,but significantly lower in the therapy group than in HD group(P＜0.01). Conclusion Preconditioning high-dose vitamin C for the dialyzer can decrease AOPP in HD patients.

Key words: AOPP, Hemodialysis, Dialyzer

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