中国血液净化

›› 2006, Vol. 5 ›› Issue (8): 426-429.

• 论著 • 上一篇    下一篇

血液透析、腹膜透析及肾移植对慢性肾衰竭患者尾加压素Ⅱ水平的影响

汪华林1 谭树芬1 刘长波1 谢 辉1 郭 颖2 俞小敏1 杨热电1 崔如健1 陈秀萌1 黄元寿1   

  1. 510120 广州，1广州医学院第一附属医院肾内科 510282 广州，2广东省广州市珠江医院肾移植科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-08-12 发布日期:2006-08-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-08-12 Published:2006-08-12

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摘要： 目的 探讨慢性肾衰竭患者血浆及尿液中尾加压素Ⅱ（Urotensin Ⅱ，UⅡ）水平变化以及血液透析、腹膜透析及肾移植对其的影响。方法 采用放射免疫方法，以正常人为对照，分别观察广州医学院第一附属医院肾内科和广东省广州市珠江医院肾移植科慢性肾衰竭未透析患者（ND组）、维持性血液透析患者（HD组）、持续性不卧床腹膜透析患者（CAPD组）、肾移植患者（KT组）血浆及尿液中的尾加压素Ⅱ水平变化。结果 ND组、HD组、PD组和KT组患者的血浆UⅡ水平较正常人显著增高(P ＜0.0001)，以HD组最高，ND组次之,PD组再次之，KT组最低；尿UⅡ排泄在ND组、HD组、PD组均显著减少（P＜0.05），但在KT组显著增加(P＜0.01)；结论 证实在非糖尿病的慢性肾衰竭患者血UⅡ水平显著增高，尿UⅡ排泄明显减少,血液透析患者和腹膜透析患者变化更为显著；肾移植患者血浆UⅡ水平增高减轻，而尿UⅡ水平显著增加； 本研究提示UⅡ是慢性肾衰竭发展过程中一个重要的多肽。

关键词: 尾加压素Ⅱ, 慢性肾衰竭, 血液透析, 持续不卧床腹膜透析, 肾移植

Abstract: Objective To observe the levels of plasma and urinary urotensin Ⅱ (UⅡ) in the chronic renal failure patients (CRF) and the influence of hemodialysis, continuous ambulance peritoneal dialysis(CAPD) and allograft renal transplantation on UⅡ levels respectively. Methods Controlled with normal subjects, the plasma and urinary UⅡ levels were examined by radioimmunoassay method in a population of 72 CRF patients who received non-dialysis (ND group), maintenance hemodialysis (HD group), continuous ambulatory peritoneal dialysis (PD group) or allograft renal transplantation (KT group) respectively. Results The plasma UⅡ levels increased significantly in all patients (P ＜0.0001)，Which in HD group was the highest,ND group the second, then PD group and KT group was the lowest. The urinary UⅡ excretion decreased in ND group、HD group、PD group obviously (P ＜0.05），but increased singnificantly in KT group(P ＜0.01)；Conclusions The investigation proved that a higher level of plasma urotensin Ⅱ and a lower urinary UⅡ excretion exist in the patients with chronic renal failure, and these changes become even more obvious in the patients who received hemodialysis or peritoneal dialysis. Allograft renal transplantation can reduce the increased levels of plasma UⅡand can increase urinary UⅡ excretion in CRF patients. The research imply that UⅡ may be an important peptide which involved in the pathophysiology of chronic renal failure.

Key words: Chronic renal falure, Hemodialysis, Continuous ambulatery peritoneal dialysis, Allograft kidney transplantation

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