中国血液净化

›› 2008, Vol. 7 ›› Issue (2): 69-70.

• 论著 • 上一篇    下一篇

维持性血液透析患者hs-CRP和IL-6与心脏结构功能变化的临床观察

张本祥 尹忠诚   

  1. 徐州医学院第二附属医院
  • 收稿日期:2007-08-15 修回日期:1900-01-01 出版日期:2008-02-12 发布日期:2008-02-12

Clinical observation of high sensitivity C-reactive protein and interleukin-6 in relation to changes of cardiac structure and function in maintenance hemodialysis patients

ZHANG Ben-xiang, 2YIN Zhong-cheng   

  1. Blood Purification Center, 1The Second Affiliated Hospital of Xuzhou Medical College
  • Received:2007-08-15 Revised:1900-01-01 Online:2008-02-12 Published:2008-02-12

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摘要： 【摘要】目的 探讨维持性血液透析(MHD)患者微炎症状态和心脏结构、功能变化的关系。方法 选择徐州医学院第二附属医院血液净化中心维持性血液透析患者共48例，同时设立健康对照组，测定空腹血清中超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)浓度值，通过彩色多谱勒测定患者的心脏结构和功能。 结果 维持性血液透析组hs-CRP、IL-6、左心室内径(LVD)、左心房内径(LAD)、室间隔厚度(IVST)、左心室后壁厚度(LVPWT)水平均显著高于正常对照组(P＜0.01)，血液透析患者hs-CRP、IL-6与LAD、LVD、IVST、LVPWT呈正相关,有80%患者存在舒张功能障碍。结论 MHD患者的hs-CRP、IL-6变化与其心脏结构变化有一定相关性。

关键词: 维持性血液透析, 超敏C-反应蛋白, 白介素-6, 心脏功能, 心脏结构

Abstract: 【Abstract】 Objective To investigate the relationship between microinflammation and changes of cardiac structure and function in maintenance hemodialysis (NHD) patients. Methods We recruited 48 patients on maintenance hemodialysis in this blood purification center, and 20 normal individuals as the controls. Serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured. Cardiac structure and function were evaluated by ultrasonic cardiography. Results Serum hs-CRP, IL-6, left ventricular dimension (LVD), left atrial dimension (LAD), interventricular septum thickness (IVST) and left ventricular dimension posterior wall thickness (LVPWT) were significantly higher in MHD patients than in controls (p<0.01). Serum hs-CRP and IL-6 were positively correlated with the values of LAD, LVD, IVST and LVPWT in MHD patients. Doppler echocardiology showed that 80% of the MHD patients had heart diastolic dysfunction. Conclusion MHD patients had higher serum hs-CRP and IL-6, which may correlate with the changes of cardiac structures.

Key words: High-sensitivity C-reactive protein (Hs-CRP), Interleukin-6 (IL-6), Cardiac structure, Cardiac function