中国血液净化

›› 2006, Vol. 5 ›› Issue (10): 714-716.

• 论著 • 上一篇    下一篇

血清肝细胞生长因子与维持性血液透析患者动脉粥样硬化的相关性研究

王银娜 刘惠兰 刘 群

  

  1. 100038 北京，首都医科大学附属复兴医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-10-12 发布日期:2006-10-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-10-12 Published:2006-10-12

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摘要： 目的 探讨血清肝细胞生长因子(HGF)与维持性血液透析患者颈动脉粥样硬化的关系。方法 选择首都医科大学附属复兴医院肾内科维持性血液透析患者50例和年龄性别相当的健康对照30例，采用双抗体夹心酶联免疫吸附(ABC-ELISA)技术检测血清肝细胞生长因子水平，用高分辨二维颈动脉超声技术检测颈动脉内-中膜厚度(IMT)、粥样硬化斑块。比较维持性血液透析患者与对照组血清肝细胞生长因子及其它临床生化指标水平，并对影响颈动脉IMT的多因素进行逐步回归分析。结果 维持性血液透析患者血清肝细胞生长因子水平较对照组明显升高 [(957.88±236.87)pg/ml和(731.55±244.05)pg/ml， (P＜0.01)]， 透析患者颈动脉粥样硬化病变程度越重，血清肝细胞生长因子水平越高。多元逐步回归分析显示，影响颈动脉IMT的因素有血清肝细胞生长因子、年龄、透析时间、高密度脂蛋白胆固醇及脂蛋白(a)。结论 血清肝细胞生长因子水平升高可能参与了维持性血液透析患者动脉粥样硬化的发生、发展。

关键词: 肝细胞生长因子, 维持性血液透析, 动脉粥样硬化

Abstract: Objective To investigate the association of serum hepatocyte growth factor(HGF) to carotid atherosclerosis in maintenance hemodialysis(MHD) patients. Methods Fifty MHD patients and thirty healthy volunteers were involved in the study. The levels of serum HGF were determined by enzyme linked immunosorbent assay. Intima-media thickness(IMT) and prevalence of atherosclerotic plaques of the extracranial common carotid artery were measured by high-resolution B-mode ultrasonography. Results Serum HGF levels in hemodialysis patients were significantly higher than those in healthy controls [(957.88±236.87)pg/ml VS (731.55 ± 244.05)pg/ml, P＜0.01]. The levels of serum HGF increased with the progression of atheroclerosis. Multiple stepwise regression analysis showed that independent risk factors associated with IMT were level of HGF, age, duration of dialysis,high density lipoprotein (HDL) and Lp(a). Conclusions Serum HGF levels in maintenance hemodialysis patients are associated with the development of atherosclerosis.

Key words: Maintenance hemodialysis, Atherosclerosis

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