中国血液净化

›› 2005, Vol. 4 ›› Issue (2): 70-72.

• 论著 • 上一篇    下一篇

肺炎衣原体的持续感染与尿毒症C-反应蛋白的关系

解汝娟 陆 红 刘睿禅   

  1. 150000 哈尔滨，哈尔滨医科大学附属一院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2005-02-12 发布日期:2005-02-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2005-02-12 Published:2005-02-12

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摘要：

目的 探讨肺炎衣原体( Cpn)持续感染与尿毒症患者C-反应蛋白(CRP)水平的关系。方法 定量 检测了50名尿毒症患者外周血清C-反应蛋白，同时应用聚合酶链反应技术检测外周血单核细胞中的肺炎衣原体DNA。结果 ①在尿毒症非透析患者及血液透析患者中，都有不同比例的C-反应蛋白水平的升高；②尿毒症非透析治疗和血液透析治疗患者中，均有不同比例的患者其外周血单核细胞中的肺炎衣原体DNA为阳性； ③C-反应蛋白水平升高组肺炎衣原体DNA阳性率高于 C-反应蛋白水平正常组， 其差异显著（P ＜0.005）。 结论 尿毒症患者 C-反应蛋白水平升高可能与肺炎衣原体持续感染有关。

关键词: C-反应蛋白, 肺炎衣原体, 尿毒症

Abstract:

Objective To investigate the relationship between the serum level of C-reactive protein(CRP) and persistent Chlamydia pneumoniae (CP) infection in patients with uremia. Methods Fifty uremia patients serum level of CRP was detected and CP DNA in peripheral blood mononuclear cells(PBMCs) was determined by polymerase chain reaction(PCR). Results ①The serum level of CRP in some patients than normal were higher; ②There were different positive rate of CP DNA in hemodialysis and non dialysis patients; ③The positive rate of CP DNA in patients with high level of CRP was significantly higher than that in patients with nomal level of CRP. Conclusions High level of CRP in the patients with uremia may be correlated with persistent CP infection.

Key words: Chlamydia pneumoniae, Uremia

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