中国血液净化

›› 2005, Vol. 4 ›› Issue (7): 357-360.

• 论著 • 上一篇    下一篇

不同透析膜对维持性血液透析患者血清氨基酸谱的影响

李铭新 薛 骏 丁 峰 陆福明 顾 勇 林善锬   

  1. 200040 上海，复旦大学附属华山医院肾脏科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2005-07-12 发布日期:2005-07-12
  • 通讯作者: 薛骏

  • Received:1900-01-01 Revised:1900-01-01 Online:2005-07-12 Published:2005-07-12

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摘要： 目的 研究不同透析膜对维持性血液透析患者血清氨基酸谱的影响及其透析液中氨基酸的丢失。方法 用高效液相色谱仪分别测定采用聚砜膜（A组）、铜仿膜（B组）、复用铜仿膜 （C组）的3组患者透析前、透析后血清氨基酸谱及其透析液中氨基酸的丢失量。结果 A组透析后血清谷氨酸、谷氨酰胺、丝氨酸、半胱氨酸、脯氨酸、酪氨酸水平降低（P＜0.05)B组血透析前后血清氨基酸谱无明显变化；C组透析后血清天冬氨酸、苏氨酸水平降低（P＜0.05）；A组和B组患者透析液中丢失的氨基酸差异无显著性，C组患者透析液中缬氨酸、亮氨酸、异亮氨酸、丝氨酸、酪氨酸的丢失明显小于A、B两组（P＜0.05）结论 不同透析膜对患者血清氨基酸谱的影响是不同的，取决于膜的物理化学特性和生物相容性。

关键词: 透析膜, 氨基酸

Abstract:

Objective To investigate the influence of different membranes on the serum amino acid patterns of hemodialysis patients. Methods Thirty maintenance hemodialysis patients were equaly divided into polysulphone,cuprophan and reuse cuprophan group. Pre- and post-dialysis serum amino acid patterns of patients and amino acid in spent dialysate were detected by high performance liquid chromatography respectively. Results The serum amino acid patterns of patients in the three groups were no difference before dialysis. However,the levels of serum glutamic acid, glutamine, serine, cysteine,proline and tyrosine in polysulphone group, meanwhile serum aspartic acid and threonine in reuse cuprophan group decreased after dialysis (P＜0.05), and no significant change of serum amino acid pattern was noted in cuprophan group. The losses of valine,leucine, isoleucine, serine and tyrosine were lower with reuse cuprophan than with cuprophan and polysulphone. Conclusions The physiochemical characteristics and biocompatibility of dialysis membrane influence the serum amino acid patterns of patients.

Key words: Amino acid

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