中国血液净化

›› 2008, Vol. 7 ›› Issue (1): 19-22.

• 论著 • 上一篇    下一篇

新型硫酸葡聚糖血脂分离系统治疗高脂血症

赵奕华1 邢昌赢1 邹元国2 孙启俊2 戴 曦1 王宁宁1 刘 佳1   

  1. 210029 1南京,南京医科大学第一附属医院肾内科 2南京市红十字血液中心
  • 收稿日期:2007-10-17 修回日期:1900-01-01 出版日期:2008-01-12 发布日期:2008-01-12

Treatment of hyperlipidemia by a new type of low density lipoprotein apheresis system with dextran sulfate

ZHAO Yi-hua , XING Chang-ying, ZOU Yuan-guo , SUN Qi-jun , DAI Xi , WANG Nin-gning, LIU Jia   

  • Received:2007-10-17 Revised:1900-01-01 Online:2008-01-12 Published:2008-01-12

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摘要： 【摘要】目的 采用新型硫酸葡聚糖(DS)血脂分离系统用于治疗高脂血症，在保证安全、有效的基础上简化血脂分离工艺，大幅度降低治疗费用。方法 选择南京医科大学第一附属医院肾内科50例患者共110例次血脂分离治疗，首先用单采机采集患者高脂血浆，按10ml/kg体重采集总量(600±100)ml。然后血浆中加入静脉注射用DS作为吸附剂，Ca2＋作为催化剂，DS特异性吸附LDL形成大颗粒，用离心法去除胆固醇、三酰甘油。结果 每次血脂分离治疗后血浆总胆固醇下降11%(6.52±0.5)和(5.8±0.4)；三酰甘油下降15%(3.85±2.1)和(3.27±1.5)；LDL-C 下降20%(4.03±0.86)和(3.2±0.52)；HDL-C保持不变(1.13±0.28)和(1.13±0.41)；白蛋白保持不变(45±5)和(45±4)，过量的Ca2＋被阳离子树脂柱完全吸附。结论 新型DS血脂分离系统工艺合理、操作过程简单、易于推广应用。特别是治疗费用低廉，更适合需要多次治疗才能纠正血脂异常的患者。

关键词: 高脂血症, 低密度脂蛋白, 单采血浆分离, 硫酸葡聚糖

Abstract: 【Abstract】Objective To achieve an effective method for the treatment of hyperlipidemia at lower cost, we developed a new type of low density lipoprotein (LDL) apheresis system with dextran sulfate. Methods Fifty patients with hyperlipidemia were treated with this method in a total of 110 times. In every treatment, 600±100 ml plasma (about 25% of the total plasma of the patient) were collected by apheresis. Dextran sulfate (LDL absorbent) and calcium chloride (as a catalyzer) solution were added to the collected plasma. Dextran sulfate selectively binds LDL-cholesterol under the catalysis of Ca2+, and the LDL-cholesterol-dextran sulfate complex was removed by centrifugation. The treated plasma was then transfused back to the patient, and the excessive calcium in the plasma was removed by a cation exchange column integrated in the transfusion set. Results After every treatment, total cholesterol in plasma reduced by 11% (from 6.52±0.5 to 5.8±0.4mmol/l), triglyceride reduced by 15% (from 3.85±2.1 to 3.27±1.5mmol/l), and LDL-C reduced by 20% (from 4.03±0.86 to 3.2±0.52mmol/l). HDL-C and albumin remained unchanged. Conclusions The new LDL apheresis system with dextran sulfate is easy to operate without using complicated equipments. This method achieves significant clinical effect at a lower cost, as compared with the other available systems. It is therefore a safe, effective and cheaper measure for the treatment of hyperlipidemia.

Key words: Low density lipoprotein, Apheresis, Dextran sulfate