关键词: 腹膜透析, 骨密度, 骨量异常, 心血管死亡

Abstract: 【Abstract】Objective To investigate the determinant factors for abnormal bone mass and the relationship between abnormal bone mass and long- term outcomes in peritoneal dialysis (PD) patients. Methods Bone mineral density was assessed by dual-energy x-ray absorptiometry. Clinical data and laboratory indices of the PD patients were collected. The time and cause of fracture or death were documented. The determinant factors of bone density and the relationship between bone density and all-cause mortality and cardiovascular mortality were analyzed in the PD patients. Results A total of 74 PD (average age 60.9±14.1 years old, 38 females) patients were enrolled in the study, with a median follow-up period of 59.5 (27.8, 98.0) months. During the follow-up period, 52 patients died, of which 26 died of cardiovascular events, and 5 had fractures. The rate of abnormal bone mass diagnosed by lumbar spine examination and that by femur examination were significant different (χ2=17.697, P＜0.001). Low BMI (OR=0.666, 95% CI 0.508～0.874, P=0.003) and advanced age (OR=1.065, 95% CI 1.007～1.126, P=0.027) were the independent risk factors for femoral abnormal bone mass. Multivariate COX regression analysis revealed that abnormal femoral bone mass increased the risk of cardiovascular mortality for 2.58 times (HR=3.582, 95% CI 1.193～10.760, P=0.023). Conclusion
Abnormal femoral bone mass is an independent predictor for the risk of cardiovascular mortality in PD patients.

Key words: Peritoneal dialysis, Bone mineral density, Abnormal bone mass, Cardiovascular mortality