中国血液净化

›› 2010, Vol. 9 ›› Issue (12): 662-664.doi: 10.3969/j.issn.1671-4091.2010.11.00

• 临床研究 • 上一篇    下一篇

高通量血液透析对患者营养状况的临床观察

徐丰博 刘惠兰 左 力 吴 华 李冀军 蔡 砺 汤天清 殷 培 程叙扬 鲍云飞   

  1. 首都医科大学附属复兴医院肾内科
  • 收稿日期:2010-07-15 修回日期:1900-01-01 出版日期:2010-12-12 发布日期:2010-12-12
  • 通讯作者: 刘惠兰

Clinical observation of nutrition status in patients using high flux membrane for hemodialysis

XU Feng-bo, LIU Hui-lan, ZUO Li, WU Hua, LI Ji-jun, CAI Li, TANG Tian-qing, YIN Pei, CHENG Xu-yang, BAO Yun-fei   

  1. 1Department of Nephrology, Beijing Fuxing Hospital, Capital University of Medical Science, Beijing 100038, China; 2Department of Nephrology, Peking University Institute of Nephrology, Peking University First Hospital, Beijing 100034, China; 3Department of Nephrology, Beijing Hospital, Beijing 100730, China; 4Department of Nephrology, First Hospital Affiliated to the PLA General Hospital, Beijing 100037, China
  • Received:2010-07-15 Revised:1900-01-01 Online:2010-12-12 Published:2010-12-12

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摘要：
【摘要】目的 研究高通量血液透析对患者营养状况的影响。方法 前瞻性、自身对照研究。136例维持性常规低通量血液透析患者，转换为高通量血液透析6个月。试验0、3、6个月分别测定患者白蛋白水平，进行食欲评分及主观综合性营养评估(subjective global assessment,SGA)。结果 对全部入选者的白蛋白水平无影响；升高了白蛋白低于25%分位患者的白蛋白，在0个月和6个月分别为(36.4± 3.1)g/L、(39.9±3.9)g/L，差异有统计学意义(P＜0.001)。此种趋势有统计学意义(P=0.0006)。高通量透析6个月后食欲评分较治疗前显著升高(P=0.0049)。SGA在试验3个月及6个月均较0个月有显著升高(P＜0.05)，趋势检验差异有统计学意义(P=0.0014)。结论 高通量血液透析对营养基线水平较低的患者营养状况有改善作用。

关键词: 高通量透析, 低通量透析, 营养状况

Abstract: Objective This prospective and self-controlled study was designed to evaluate whether change from low-flux hemodialysis to high-flux hemodialysis could improve patients’ nutrition status. Methods We recruited 136 patients on maintenance low-flux hemodialysis. We then changed the low-flux dialyzer to high-flux F60 or FX60 dialyzer for hemodialysis without changing any other dialysis prescriptions. Plasma albumin, appetite score and subjective global assessment (SGA) were assessed before the change and after the change for 6 months. Results Plasma albumin remained unchanged in all patients after the change. In patients whose albumin increased lower than 25 percentile, plasma albumin was 36.4±3.1g/L, and 39.9±3.9g/L (P<0.001) before the change and after the change for 3 and 6 months, respectively. Appetite score increased (P=0.0049) after the change for 6 months. SAG score also increased (P<0.05) after the change for 3 and 6 months. Conclusions The results show that the shift from low-flux to high-flux hemodialysis improves the nutrition status in maintenance hemodialysis patients.

Key words: Low flux hemodialysis, Nutrition status