中国血液净化

›› 2011, Vol. 10 ›› Issue (4): 178-180.doi: 10.3969/j.issn.1671-4091.2011.04.00

• 临床研究 • 上一篇    下一篇

维持性血液透析患者血清白细胞介素6、白细胞介素8和肿瘤坏死因子水平变化及临床意义

宋 洁 李 辉 张晓东 石理华 李 瑛   

  1. 武警医学院附属医院肾病科
  • 收稿日期:2010-10-11 修回日期:1900-01-01 出版日期:2011-04-12 发布日期:2011-04-12
  • 通讯作者: 李辉

The clinical significance of changes in serum IL-6, IL-8 and TNF-?in maintenance hemodialysis patients

SONG Jie, LI Hui, ZHANG Xiao-dong, SHI Li-hua, LI Ying   

  1. Department of Nephrology, the Affiliated Hospital of Chinese People’s Armed Police Forces Medical College, Tianjin 300162, China
  • Received:2010-10-11 Revised:1900-01-01 Online:2011-04-12 Published:2011-04-12

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摘要： 【摘要】 目的 观察维持性血液透析(maintenance hemodialysis,MHD)患者血清细胞炎性因子白细胞介素6(interleukin-6,IL-6)、IL-8和肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)浓度的变化并探讨其临床意义。 方法 选取2009年4月至2010年6月在武警医学院附属医院血液净化中心MHD治疗的尿毒症患者80例作为病例组，选取20例正常健康体检者作为对照组，分别检测两组血清IL-6、IL-8、TNF-α椎鞍 (albumin,Alb)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)的浓度。 结果 病例组血清IL-6、IL-8、TNF-αC、LDL-C明显高于对照组(P＜0.01)， 血清Alb明显低于对照组(P＜0.01)，提示微炎症状态的存在。相关分析显示，病例组IL-6、IL-8和TNF-嵊階lb之间呈负相关关系，与TC和LDL-C之间呈正相关关系。 结论 MHD患者体内存在微炎症状态，其与营养不良和脂质代谢紊乱有关。

关键词: 白细胞介素6, 白细胞介素8, 肿瘤坏死因子幔 微炎症, 维持性血液透析

Abstract: 【Abstract】 Objective To observe the changes of serum IL-6, IL-8 and TNF-α and their clinical significance in maintenance hemodialysis patients. Methods We selected 80 uremic patients undergoing maintenance hemodialysis (MHD group) during April 2009 to June 2010 in the Blood Purification Center, Department of Nephrology, the Affiliated Hospital of Chinese People’s Armed Police Forces Medical College, and 20 healthy individuals as the normal control (control group). Their serum IL-6, IL-8, TNF-α, albumin (ALB), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), creatinine (Cr) and blood urea nitrogen (BUN) were measured. Results Serum levels of IL-6, IL-8, TNF-α, TC and LDL-C were significantly higher in MHD patients than in control group (P<0.01), and ALB was significantly lower in MHD group. Correlation analysis indicated that IL-6, IL-8 and TNF-α were negatively correlated with ALB, and were positively correlated with TC and LDL-C in MHD patients. Conclusion Microinflammatory status existed in MHD patients, possibly relating to the malnutrition and dyslipidemia in these patients.

Key words: Interleukin-6, Tumor necrosis factor-α, Maintenance hemodialysis, Microinflammatory status