中国血液净化

中国血液净化 ›› 2012, Vol. 11 ›› Issue (06): 293-297.doi: 10.3969/j.issn.1671-4091.2012.06.00

• 临床研究 • 上一篇    下一篇

强化超滤对老年维持性血液透析患者高血压的影响

邓英辉 王君梅 林 娜 贾 强   

  1. 首都医科大学宣武医院肾内科
  • 收稿日期:2012-02-16 修回日期:1900-01-01 出版日期:2012-06-12 发布日期:2012-06-12
  • 通讯作者: 邓英辉

Intensive ultrafiltration on hypertension in elderly hemodialysis patients

DENG Ying-hui, WANG Jun-mei, LIN Na, JIA Qiang   

  • Received:2012-02-16 Revised:1900-01-01 Online:2012-06-12 Published:2012-06-12

RichHTML

0

PDF

555

摘要： 【摘要】 目的 观察通过强化超滤以进一步降低干体重对老年维持性血液透析患者高血压的影响。 结果 基点处两2组患者干体重体质量基本相同[(64.81±13.26)Kg和(64.49±13.83)Kg，t=0.508，P=0.618]，透析前收缩压[(155.12±13.77)mmHg和(155.47±9.92)mmHg，t=0.086，P= 0.932](1 mmHg=0.133Kpa)及舒张压[(78.59±11.41）mmHg和(78.71±10.96)mmHg，t=0.031，P= 0.976]未见明显差异(P＞0.05)。观察第28周时，对照2组患者干体重体质量分别为(65.56±13.75)Kg和(62.22±13.34)Kg，较前下降(0.36±1.12)Kg和(2.27±1.03)Kg，超滤组干体质量低于对照组(t=3.785，P=0.002)。保持稳定，透析前收缩压为(155.29±12.73)mmHg和(139.82±4.14)mmHg，分别和较前下降(0.53±4.57)mmHg和(14.29±10.55)mmHg，超滤组收缩压低于对照组(t=4.767，P =0.000)透析前舒张压分别为(79.12±9.84)mmHg和(68.24±3.57)mmHg，分别较前下降(0.53±4.57)mmHg和(9.00±9.46)mmHg，超滤组舒张压低于对照组(t=4.298，P=0.000)。 结论 通过强化超滤降低干体质量，有利于老年维持性血液透析患者高血压的控制。

关键词: 血液透析, 超滤, 血压

Abstract: 【Abstract】 Objective To investigate whether additional ultrafiltration to further reduce dry body weight improves blood pressure (BP) control among elderly hemodialysis patients with hypertension. Methods Thirty-four aged maintenance hemodialysis (MHD) patients with hypertension were divided into control and ultrafiltration groups. In control group, conventional dialysis dose and ultrafiltration volume were used. In ultrafiltration group, reduction of dry body weight to a minimal tolerable level was gradually achieved by slightly increasing ultrafiltration volume. After 28 weeks, dry body weight and BP were compared between the two groups. Results In control group and ultrafiltration group at the baseline condition, dry body weight was 64.81±13.26 kg and 64.49±13.83 kg (t=0.508, P=0.618), systolic BP was 155.12±13.77 mmHg and 155.47±9.92 mmHg (t= 0.086, P=0.932), and diastolic BP was 78.59±11.41 mmHg and 78.71±10.96 mmHg (t=0.031, P= 0.976), respectively, without significant differences between the two groups. In control group and ultrafiltration group after the treatment for 28 weeks, dry body weight was 65.56±13.75 kg and 62.22±13.34 kg (reduced by 0.36±1.12 kg and 2.27±1.03 kg), systolic BP before dialysis session was 155.29±12.73 mmHg and 139.82±4.14 mmHg (reduced by 0.53±4.57 mmHg and 14.29±10.55 mmHg), and diastolic BP before dialysis session was 79.12±9.84 mmHg and 68.24±3.57 mmHg (reduced by 0.53±4.57 mmHg and 9.00±9.46 mmHg), respectively. Patients in ultrafiltration group showed more reduction in dry body weight (t=3.785, P=0.002), systolic BP (t=4.767, P=0.000), and diastolic BP (t=4.298, P=0.000) than those in control group. Conclusion The decrease of dry body weight through intensive ultrafiltration is an effective approach to improve BP control in elderly hemodialysis patients with hypertension.

Key words: Hemodialysis, Ultrafiltration, Blood pressure