中国血液净化

中国血液净化 ›› 2014, Vol. 13 ›› Issue (03): 137-139.doi: 10.3969/j.issn.1671-4091.2014.03.003

• 临床研究 • 上一篇    下一篇

维持性血液透析患者骨密度的测定结果与分析

张宇梅1,耿磊2,张凌1,付芳婷1,李文歌1   

  1. 1. 中日友好医院肾内科
    2. 内蒙古包头市蒙医中医医院
  • 收稿日期:2013-09-02 修回日期:2013-11-19 出版日期:2014-03-12 发布日期:2014-03-12
  • 通讯作者: 李文歌 wenge_lee2002@126.com E-mail:wenge_lee2002@yahoo.com
  • 基金资助:

    国家科技支撑计划课题(2001BAI10B007)资助

Bone density measurement in patients on maintenance hemodialysis

  • Received:2013-09-02 Revised:2013-11-19 Online:2014-03-12 Published:2014-03-12

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摘要： 目的 对维持性血液透析患者骨密度情况进行测定研究，了解骨质疏松患病情况。方法 选择中日友好医院肾内科血液净化中心141例维持性血液透析患者，按性别、透析龄、血清全段甲状旁腺素(intact parathyroid hormone，iPTH）值分组，记录患者的年龄、身高、体重等资料。应用跟骨超声骨密度测定仪进行跟骨密度测定，测定iPTH水平，用SSPS软件进行统计学分析。结果 骨质疏松总患病率为51.77%，骨量减少为41.84%。女性骨质疏松患病率为65.00%，明显高于男性34.42%（P＜0.05），随着透析龄增加，患者的骨质疏松患病率逐渐升高，iPTH值各组比较差异无明显性。结论 血液透析患者普遍存在低骨量，骨质疏松患病率高，应给予针对性治疗。

关键词: 血液透析, 骨密度, 跟骨超声定量法

Abstract: Objective To explore bone mineral loss and osteoporosis in patients on maintenance hemodialysis (MHD). Methods We recruited 141 MHD patients treated in the Blood Purification Center of Nephrology Department, China-Japan Friendship Hospital. They were then grouped based on sex, MHD age, and serum intact parathyroid hormone (iPTH) level. Their age, body weight and height were recorded, serum iPTH was measured, and calcaneal bone mineral density was assayed by a calcaneal quantitative ultrasound instrument. Data were analyzed by the software SPSS. Result The prevalence of osteoporosis was 51.77%,
and that of osteopenia was 41.84%. The prevalence of osteoporosis was higher in females (65.00%) than in males (34.42%; χ2 = 13.07, P <0.05), increased gradually with MHD age, but was indifferent among the groups with various iPTH levels. Conclusion Calcaneal osteopenia and osteoporosis were prevalent in MHD patients.

Key words: Hemodialysis, Bone density, Quantitative ultrasound measurement