中国血液净化

中国血液净化 ›› 2014, Vol. 13 ›› Issue (03): 152-155.doi: 10.3969/j.issn.1671-4091.2014.03.007

• 临床研究 • 上一篇    下一篇

使用酸性氧化电位水消毒血液透析浓缩液容器的安全性和有效性研究

张宜苗,田爱辉,左力   

  1. 北京大学第一医院肾脏内科
  • 收稿日期:2013-12-06 修回日期:2014-01-13 出版日期:2014-03-12 发布日期:2014-03-12
  • 通讯作者: 左力 zuoli@bjmu.edu.cn E-mail:zym9701@sina.com

The study on efficiency and safety of disinfection for hemodialysis concentrate fluid container by acidic electrolyzed oxidizing water

  • Received:2013-12-06 Revised:2014-01-13 Online:2014-03-12 Published:2014-03-12

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摘要： 【摘要】目的 通过研究酸性氧化电位水对血液透析浓缩液容器消毒的有效性和安全性，探讨血液透析浓缩液盛放器安全便捷的消毒解决方案。方法 在北京市某三甲医院血液透析中心随机选取当天透析结束后的B液塑料桶80个,用自来水接种细菌后，分别用4 种消毒技术路线对B液桶进行消毒, 容器盛满酸性氧化电位水并以2L/min的速度流动消毒：（1）酸性氧化电位水消毒5分钟后不冲洗、盖好桶盖，（2）酸性氧化电位水消毒5分钟后不冲洗、不盖桶盖，（3）酸性氧化电位水消毒5分钟后，1500ml反渗水冲洗、盖好桶盖，（4）酸性氧化电位水消毒10分钟后，1500ml反渗水冲洗、盖好桶盖,同时直接培养自来水及当天透析结束后剩余的B液作为对照。 结果 1.四种消毒技术路线对血液透析浓缩液容器消毒均有效，但不冲洗且盖好桶盖时残留氯量大，超过透析用水的安全范围。不冲洗无论盖好桶盖与否残留内毒量均较大。2.酸性氧化电位水消毒5分钟、10分钟后，冲洗后盖好桶盖具有良好的有效性及安全性,这两种路线间无明显差异。 结论 酸性氧化电位水用于血液透析浓缩液容器的消毒具有良好的有效性和安全性，酸性氧化电位水消毒5分钟后冲洗、盖好桶盖的消毒方法是较优选择。

关键词: 酸性氧化电位水, 消毒, 血液透析, 浓缩液容器

Abstract: Objective The aim of this study was to evaluate the efficiency and safety of acidic electrolyzed oxidizing water (AEOW) for disinfecting the concentrated dialysate containers. Methods A total of 80 containers for bicarbonate concentrated dialysate were collected from one hemodialysis center. The containers were contaminated by the bacteria in tap water, and the efficiency and safety of the four disinfection protocols were then compared. Results The four protocols were all effective for disinfecting the concentrated dialysate containers (P ＜0.05). After the disinfection of protocol A, however, residual chlorine in dialysate was higher than the upper safety limit, and was also higher than that after the disinfection of protocols B, C and D (3.31± 1.69 mg, 0.03±0.02 mg, 0.03±0.08 mg, and 0.07 ± 0.13 mg using protocol A, B, C and D, respectively; P ＜ 0.05). Residual endotoxin was higher using protocols A and B than using protocols C and D (P ＜0.05), but was indifferent between protocols C and D. After the disinfection of protocols C and D, residual chlorine was 0.03±0.08 mg and 0.07±0.13 mg, respectively, and residual endotoxin was 29.54±28.60 EU and 21.87±17.37 EU, respectively, significantly lower than those by protocols A and B, and indifferent between protocols C and D (P >0.05). Conclusions AEOW was effective and safe for disinfecting the concentrated dialysate containers. The optimal disinfection procedure included treatment with AEOW for 5 minutes followed by rinse and lid covering.

Key words: Acidic Electrolyzed Oxidizing Water(AEOW), Disinfect, Hemodialysis(HD), Fluid Concentrate Container