中国血液净化

中国血液净化 ›› 2014, Vol. 13 ›› Issue (03): 156-160.doi: 10.3969/j.issn.1671-4091.2014.03.008

• 临床研究 • 上一篇    下一篇

血液透析患者血清脂肪细胞型脂肪酸结合蛋白水平与动脉粥样硬化相关性的初步探讨

吴晶,袁伟杰,王玲,郝静,谷立杰,王轩,黄艳茹   

  1. 上海交通大学附属第一人民医院肾内科
  • 收稿日期:2013-08-27 修回日期:2013-09-26 出版日期:2014-03-12 发布日期:2014-03-12
  • 通讯作者: 袁伟杰 ywj4169@163.com E-mail:ywj4169@163.com

The relationship between serum adiopocyte fatty acid binding protein and atherosclerosis in hemodialysis patients

  • Received:2013-08-27 Revised:2013-09-26 Online:2014-03-12 Published:2014-03-12

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摘要： 目的： 观察血液透析（HD）患者血清脂肪细胞型脂肪酸结合蛋白（adioPocyte fatty acid binding Protein, A-FABP, FABP4）的变化，并初步探讨其与HD动脉粥样硬化(AS)的相关性。方法： 选取HD患者29例为研究对象（HD组），20例健康体检者为对照（HC组），应用酶联免疫吸附试验(ELISA)测定两组血清A-FABP、IL-6和MCP-1的水平。采用彩色多普勒超声技术测定患者颈总动脉内膜-中层（IMT）厚度。再根据是否伴有大血管病变，将HD组分为HD合并AS组（HD+AS组）、HD不合并AS组（HD-AS组）结果：HD组患者与HC组比较，血清A-FABP、FFA水平显著升高（P＜0.05）。经pearson相关分析，A-FABP与FFA存在显著相关（r=0.939，P＜0.01），A-FABP与IL-6、MCP-1亦存在正相关关系。HD+AS组患者血清 A-FABP水平高于CKD-AS组，且存在统计学差异（P＜0.1）。结论： HD患者血清A-FABP及FFA水平高于健康人群，AS的形成可能与血清A-FABP水平的升高有关。推测A-FABP可能主要通过促进炎症反应和活化巨噬细胞参与AS的形成。

关键词: 血液透析（HD）, 动脉粥样硬化（AS）, 脂肪细胞型脂肪酸结合蛋白（A-FABP）, 游离脂肪酸（FFA）

Abstract: Objective To investigate the changes of serum adiopocyte fatty acid binding protein (AFABP, FABP4) and its correlation to atherosclerosis in hemodialysis patients. Methods Twenty-nine hemodialysis patients and 20 health controls were involved in this study. Serum A-FABP, free fatty acids (FFA), IL- 6, monocyte chemotactic protein 1 (MCP-1) were measured by enzyme-linked immunosorbent assay (ELISA). Intima-media thickness was measured by color Doppler ultrasonography. Results Serum A-FABP and FFA were higher in hemodialysis patients than in healthy controls (P＜0.05). In hemodialyis patients, serum A-FABP level was positively correlated with serum FFA level (r=0.939, P＜0.01), IL-6, and MCP-1. Serum AFABP was higher in the 19 hemodialysis patients with vascular atherosclerosis than in the 10 hemodialysis patients without vascular atherosclerosis (P＜0.01). Conclusion Serum A-FABP may play an important role in the progression of vascular atherosclerosis in chronic kidney disease patients.

Key words: Hemodialysis, atherosclerosis, adiopocyte fatty acid binding protein, free fatty acid