中国血液净化

中国血液净化 ›› 2014, Vol. 13 ›› Issue (06): 454-457.doi: 10.3969/j.issn.1671-4091.2014.06.009

• 临床研究 • 上一篇    下一篇

尿血管紧张素原与IgA肾病患者新月体形成相关性分析

郑亦沐,郑丹侠,王松,阿拉塔,王悦   

  1. 北京大学第三医院肾内科
  • 收稿日期:2014-03-17 修回日期:2014-04-04 出版日期:2014-06-12 发布日期:2014-06-12
  • 通讯作者: 王悦 bjwangyue@sina.com E-mail:bjwangyue@sina.com

Corelation of urinary angiotensinogen with formation of crescent in IgA nephropathy patients

  • Received:2014-03-17 Revised:2014-04-04 Online:2014-06-12 Published:2014-06-12
  • Contact: Yue WANG E-mail:bjwangyue@sina.com

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摘要： 目的 探讨IgA肾病（IgAN）患者尿血管紧张素原（AGT）与肾小球新月体形成的关系。方法 入选北京大学第三医院肾内科2011年3月-2013年6月经肾脏活检病理检测证实的IgAN患者45例，ELISA检测尿AGT水平，计算新月体指数，分析二者的相关性。结果 IgAN患者尿AGT水平显著高于正常对照(212.3±276.1 vs. 6.6 ± 4.9 μg/g, p<0.05)，有新月体患者显著高于无新月体患者(272.3±329.7 vs.143.6±187.2μg/g, p<0.05)，新月体指数≥10%的患者显著高于新月体指数<10%的患者(375.8±391.9 vs. 201.3±186.3 μg/g, p<0.05)，尿AGT与新月体指数(r=0.483，p=0.001)、24小时尿蛋白(r=0.618, p=0.000)水平正相关，与血白蛋白（r=-0.535, p=0.000）水平负相关。结论 IgAN患者尿液AGT水平可能反映肾组织新月体形成。

关键词: IgA肾病, 新月体, 蛋白尿, 尿血管紧张素原, 肾素-血管紧张素系统

Abstract: Objective To analyze the relationship between urinary angiotensinogen(AGT) and the formation of crescent in IgA nephropathy(IgA N) patients. Methods Between March 2011 and June 2013, 45 patients who were diagnosed with IgA nephropathy by renal biopsy in the Peking University Third Hospital were chosen in the study. Enzyme linked immunosorbent assay ( ELISA ) was applied to detect the levels of urinary AGT. Crescent index was calculated and correlation analysis was processed between urinary AGT and crescent index. Results T he urinary level of AGT in IgA N group increased significantly compared with that of control group (212.3±276.1 vs. 6.6 ± 4.9 μg/g, p<0.05). The level of urinary AGT in IgA N patients with crescent formation increased compared with that of non crescent group (272.3±329.7 vs.143.6±187.2μg/g, p<0.05).The level of urinary AGT of index o f crescent≥10% group increased compared with that of the index of crescent <10% group (375.8±391.9 vs. 201.3±186.3 μg/g, p<0.05). T he level of urinary AGT was positively correlated with index o f crescent(r=0.483，p=0.001) and 24-h urine protein (r=0.618, p=0.000), and negatively correlated with serum albumin(r= - 0.535, p=0.000).Conclusion The levels of urinary AGT may reflect the renal tissue of crescent formation in IgA N patients.

Key words: IgA nephropathy, Crescent, Proteinuria, Urinary angiotensinogen, renin angiotensin system