中国血液净化

中国血液净化 ›› 2015, Vol. 14 ›› Issue (09): 569-571.doi: 10.3969/j.issn.1671-4091.2015.09.015

• 中心管理与技术 • 上一篇    下一篇

常规内毒素检测对降低血液透析治疗风险的临床价值

祝荣文,杨亦彬,刘永,尚会强,李列宽   

  1. 遵义医学院附属医院血液净化室
  • 收稿日期:2015-04-15 修回日期:2015-07-21 出版日期:2015-09-12 发布日期:2015-09-12

The clinical value of regular endotoxin detection to decrease risk of hemodialysis treatment

  • Received:2015-04-15 Revised:2015-07-21 Online:2015-09-12 Published:2015-09-12

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摘要： 【摘要】目的建立血液透析用反渗水和透析液内毒素检测制度，探讨透析用反渗水和透析液内毒素的合理限值，降低血液透析治疗风险。方法根据《中国药典》2010 版第二部收载的细菌内毒素光度检测方法，即ATI 动态试管仪定量法测定透析用反渗水和透析液内毒素含量。结果参照ISO 标准，共检测15 家医院的透析室，其中14 家反渗水内毒素﹤0.25EU/ml，合格率为93.3%。8 家透析液内毒素﹤0.50EU/ml，合格率为53.3%。整改后反渗水及透析液合格率达100%。结论加强对透析过程各环节持续质量控制，及时采取干预措施，对提高透析质量，降低血液透析治疗风险是非常有帮助的。

关键词: 血液透析, 透析液, 反渗水, 内毒素, 治疗风险

Abstract: 【Abstract】Objective To establish system of regular water of hemodialysis and detecting toxin in dialysate,and to probe into the reasonable limiting range of water of hemodialysis and detecting toxin in dialysate, in purpose of decreasing the risk of hemodialysis treating. Methods According to Bacterial endotoxin photometricdetection method which is included in Chinese Pharmacopoeia(Ch.p) 2010 second edition, experimenting by adopting ATI dynamic test tube apparatus to quantitive determinate reverse osmosis(RO) and volumeof toxin in dialysate(reference to ISOStandard). Results after scrutiny for fifteen hospital in total, it is found that toxin in dialysate of above including fourteen hospital is Below 0.25EU/ml, qualified rate reach93.3 percent, and eight hospital is below 0.50 EU/ml, qualified rate reach53.3 percent. after rectification，rate of RO and dialysate reach 100 percent. Conclusions As a result of strengthening persistent quality control in each progress for hemodialysis, taking intervention timely,and improving quality of hemodialysis, to decrease
treating risk of hemodialysis is wholly possible and feasible.

Key words: Hemodialysis, Dialysate, Reverse Osmosis(RO), Endotoxin, Treatment Risk