关键词: 慢性肾脏病, 矿物质和骨异常, 血钙, 血磷, 甲状旁腺激素

Abstract: Chronic kidney disease- mineral and bone disorder (CKD-MBD) is a common complication during the progression of CKD, closely relating to the hospitalization rate, poor quality of life, cardiovascular calcification and cardiovascular or all- cause mortality in CKD patients. It is an important issue for clinical workers to identify the CKD-MBD related control targets of serum calcium, phosphorus and PTH values, and a series of clinical guidelines and consensus have been provided in the past years. The target values for serum calcium and phosphorus are basically consistent, i.e. to achieve and maintain the values in the normal reference ranges when possible. The calcium-phosphorus product is mainly affected by the phosphorus concentration and has less significance. The target value for PTH is quite broad. The suggestion in KDIGO guidelines that intact PTH (iPTH) should be controlled in 2-9 times of the upper normal limit is widely mentioned but is controversial. However, a narrow range for iPTH cannot be defined in the published results so far. Clinically, the dynamic changes of CKD-MBD parameters are more valuable than a single value of one parameter.