中国血液净化

中国血液净化 ›› 2017, Vol. 16 ›› Issue (06): 370-372.doi: 10.3969/j.issn.1671-4091.2017.06.004

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血液透析患者血管钙化相关因素分析及防治策略

白冰1,王彩丽1,张银利1   

  1. 1. 内蒙古自治区包头医学院第一附属医院肾内科
  • 收稿日期:2016-11-07 修回日期:2017-04-13 出版日期:2017-06-12 发布日期:2017-06-14
  • 通讯作者: 王彩丽 WangCaili213@163.com E-mail:wangcaili213@163.com

Analyses of related factors and prevention strategy for vascular calcification in hemodialysis patients

  • Received:2016-11-07 Revised:2017-04-13 Online:2017-06-12 Published:2017-06-14

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摘要： 慢性肾脏病终末期患者最终的结局是维持性透析，由于自身的条件不同，有些人选择了血液透析(Hemodialysis,HD)，有些人选择了腹膜透析。HD 患者发生血管钙化的因素较多，既有传统的因素，如：血脂异常、高血压、糖尿病等，也有非传统的因素，如成纤维细胞生长因子23(fibroblast growth factor23,FGF23)水平、血清klotho 水平、细胞外的晚期糖基化终末产物受体(Receptor for advanced glycation end products,RAGE)结合蛋白S100A12(en-rage)、血清可溶性肿瘤坏死因子样凋亡微弱诱导剂(Serum soluble tumor necrosis factor like weak inducer of apoptosis,STWEAK)水平、血清胎球蛋白A(Serum immunoglobulin A,fetuin-A)水平等。本综述进一步阐述哪些因素参与了HD 患者的血管钙化，同时针对这些因素明确了降低透析患者血管钙化风险的一些策略。

关键词: 血液透析, 血管钙化, 因素分析

Abstract: The final treatment step for chronic kidney disease patients is maintenance dialysis. The selection of hemodialysis (HD) or peritoneal dialysis (PD) is based on conditions of the patients. HD patients have more factors for vascular calcification. The traditional factors include dyslipidemia, hypertension and diabetes. The nontraditional factors include the serum levels of FGF-23, Klotho, the extracellular end product receptor for advanced glycation end products (RAGE) binding protein S100A12 (EN-RAGE), serum soluble tumor necrosis factor like weak inducer of apoptosis (STWEAK), and fetuin A. This review further describes the factors involved in vascular calcification in hemodialysis patients and the strategies to reduce the risk of vascular calcification in dialysis patients.

Key words: Hemodialysis, vascular calcification, factor analysis