中国血液净化

中国血液净化 ›› 2018, Vol. 17 ›› Issue (06): 361-365.doi: 10.3969/j.issn.1671-4091.2018.06.001

• 专题 •    下一篇

慢性肾脏病血管钙化的研究进展

吴明1,林评兰1,叶朝阳1   

  1. 1.上海中医药大学附属曙光医院肾病科上海中医药大学中医肾病研究所
  • 收稿日期:2018-01-29 修回日期:2018-03-14 出版日期:2018-06-12 发布日期:2018-06-20
  • 通讯作者: 叶朝阳 yechaoyang63@126.com E-mail:yechaoyang63@126.com
  • 基金资助:

    浦东新区中西医结合慢性肾病学科群(PWZxq2017-07)；上海中医药大学附属曙光医院四明基金青年项目(SGKJ-201712)；上海市卫生和计划生育委员会科研课题面上项目(201740193)

Recent advances in vascular calcification in chronic kidney disease patients

  • Received:2018-01-29 Revised:2018-03-14 Online:2018-06-12 Published:2018-06-20

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摘要： 【摘要】慢性肾脏病(chronic kidney disease，CKD)是诱发心血管疾病的重要危险因素。血管壁钙化在一定程度上导致了心血管疾病的发生发展。CKD 患者体内钙、磷水平升高，是血管平滑肌细胞(vascular smooth muscle cell，VSMC)钙化的关键启动和进展因素。血管钙化与骨化过程类似，是钙化促进因子和抑制因子相互平衡的复杂过程。本文综述了血管钙化的生理机制、体内体外模型的研究进展、以及血管钙化领域最新研究热点。

关键词: 慢性肾脏病, 血管钙化, 钙, 磷

Abstract: 【Abstract】Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease. Calcification of vascular wall promotes the development of cardiovascular disease. Elevated levels of calcium and phosphorus in CKD patients stimulate the calcification of vascular smooth muscle cell (VSMC). Vascular calcification is a complex process with the balance of calcification promoting factors and inhibitory factors, similar to the process of ossification. In this paper, we reviewed the physiological mechanism of vascular calcification, the in vitro and in vivo research models and the hot topics in the research field of vascular calcification.

Key words: Chronic kidney disease, vascular calcification, calcium, phosphorus