关键词: 钙化防御, 硫代硫酸钠, 碳酸镧, 腹膜透析

Abstract: 【Abstract】Calciphylaxis, also named as uremic arterioles disease, is a rare but life- threatening obliterative vasculopathy occurring in dialysis patients. It is frequently seen in abdomen, breast and extremities. Early lesions can appear as indurations, erythematous papules, nodules, plaques or bullae, finally becoming necrotic foci and painful ulcers with high mortality. In this paper, we report a case with calciphylaxis and severe secondary hyperparathyroidism. We treated this patient with sodium thiosulfate as well as calcium-free phosphate binder (lanthanum carbonate) and her painful skin ulcers improved significantly soon after the treatment. Parathyroidectomy was carried out after several months. Until now, no recurrence of calciphylaxis has been observed and her serum calcium and phosphorous levels remain in normal ranges. This case demonstrates that sodium thiosulfate combined with lanthanum carbonate is an effective therapy for calciphylaxis.

Key words: calciphylaxis, sodium thiosulfate, lanthanum carbonate, peritoneal dialysis