中国血液净化

中国血液净化 ›› 2019, Vol. 18 ›› Issue (01): 26-29.doi: 10.3969/j.issn.1671-4091.2019.01.006

• 临床研究 • 上一篇    下一篇

血浆置换治疗急性格林巴利综合征疗效的影响因素分析

黄振华1,2,孔德燕3,周红卫1   

  1. 1广西医科大学第一附属医院血液净化科
    2广西壮族自治区民族医院血液净化科
    3广西医科大学第二附属医院神经内科
  • 收稿日期:2018-07-27 修回日期:2018-08-30 出版日期:2019-01-12 发布日期:2018-12-25
  • 通讯作者: 黄振华 757445396@qq.com E-mail:757445396@qq.com
  • 基金资助:

    广西科学研究与技术开发计划项目[桂科攻(14124004-1-3)]

The influence factors on the effect of plasma exchange in the treatment of patients with acute Guillain- Barré syndrome

  • Received:2018-07-27 Revised:2018-08-30 Online:2019-01-12 Published:2018-12-25

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摘要： 【摘要】目的探讨血浆置换(plasma exchange，PE)治疗急性格林巴利综合征(Green-Barré syndrome，GBS)疗效的影响因素。方法118 例急性GBS 患者分为PE 治疗组和未行PE 治疗组。比较2 组疗效的差异并分析影响PE 治疗效果的因素。结果PE 治疗组急性GBS 总有效率(73.5%)高于未行PE治疗组(54%)，2 组总有效率比较差异有统计学意义(P =0.023)。Logistic 回归分析发现PE 次数(OR2.123 95% CI:1.168～5.321,P =0.019)和轴索损害(OR 4.758 95% CI:1.475～15.350,P =0.009)是影响PE 治疗急性GBS 疗效的独立影响因素。结论PE 是治疗急性GBS 的一种有效的方法，而PE 次数和轴索损害可能是PE治疗急性GBS 疗效的独立影响因素，这有待进一步的研究证实。

关键词: 格林巴利综合征, 血浆置换, 疗效, 影响因素

Abstract: 【Abstract】Objective To analyze the influence factors on the effect of plasma exchange (PE) in the treatment of patients with acute Guillain- Barré syndrome (GBS). Methods A total of 118 acute GBS patients were divided into PE group and non- PE group. Therapeutic effect was compared between the two groups and the influence factors affecting the PE effect were investigated. Results Fifty GBS patients in PE group were responsive to PE with the effective rate of 73.5%, while 27 GBS patients in non-PE group were responsive with the effective rate of 54% (P=0.023). Multivariate analyses revealed that the number of PE (odds ratio 2.123) and axonal damage (odds ratio 4.758) were the two independent influence factors for the therapeutic effect of PE in the treatment of acute GBS patients. Conclusion PE is an effective treatment for acute GBS. The number of PE and the axonal damage are the two independent influence factors for the therapeutic effect of PE in the treatment of acute GBS patients. Further study is required to validate the findings of this study.

Key words: guillain-Barré, syndrome, plasma exchange, therapeutic effect, influence factors.