中国血液净化

中国血液净化 ›› 2019, Vol. 18 ›› Issue (02): 124-126.doi: 10.3969/j.issn.1671-4091.2019.02.012

• 综述 • 上一篇    下一篇

血镁与慢性肾脏病患者血管钙化和钙化防御的相关性

蔡士铭1,李月红1   

  1. 1. 清华大学附属北京清华长庚医院肾内科清华大学临床医学院
  • 收稿日期:2018-09-20 修回日期:2018-08-06 出版日期:2019-02-12 发布日期:2019-01-25
  • 通讯作者: 李月红 liyuehong0616@163.com E-mail:liyuehong0616@163.com
  • 基金资助:

    首都临床特色应用研究（Z181100001718129）

Correlation between blood magnesium level and vascular calcification and calciphylaxis in chronic kidney disease patients

  • Received:2018-09-20 Revised:2018-08-06 Online:2019-02-12 Published:2019-01-25

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摘要： 【摘要】镁参与许多反应过程，包括骨代谢、神经传导、心脏节律和血管收缩等。慢性肾脏病(chronic kidney disease，CKD)患者的研究多着重于钙、磷、甲状旁腺素和骨代谢异常。研究发现透析患者低镁血症与血管钙化、心血管疾病(cardiovascular disease, CVD)和全因死亡率有相关性。钙化防御在糖尿病肾病导致的终末期肾病(end stage renal disease，ESRD)患者尤为突出，高磷、高钙及尿毒症环境加重钙化防御的风险。本文就CKD患者血镁与血管钙化和钙化防御的相关性和机制进行综述。

关键词: 血镁, 血管钙化, 钙化防御, 慢性肾脏病

Abstract: 【Abstract】Magnesium is an important ion in the human body and participates in many metabolic processes including bone metabolism, nerve conduction, heart rhythm and vasoconstriction. Studies have focused on calcium, phosphorus, parathyroid hormone and abnormal bone metabolism in patients with chronic kidney disease (CKD) and end stage renal disease (ESRD). Recent studies find that dialysis patients with hypomagnesemia have increased risks of vascular calcification, cardiovascular disease and all-cause mortality rate. ESRD patients, especially those complicated with diabetes, hyperphosphatemia, hypercalcemia and uremia environment, have high risk of calciphylaxis. In this review, we introduce the correlation and mechanism between blood magnesium level and vascular calcification and calciphylaxis in CKD patients.

Key words: Magnesium, Vascular calcification, Calciphylaxis, Chronic kidney disease