【Abstract】Objective To explore the factors relating to intradialytic blood pressure variability and to analyze the relationship between blood pressure variability and cardiac functional indices in maintenance hemodialysis (MHD) patients. Methods MHD patients treated in the Hemodialysis Division of Peking University People’s Hospital from October 1 to 31, 2017 were recruited. Their demographic data, biochemical examinations,echocardiography and intradialytic blood pressure were collected. Pearson and multivariate regression analyses were performed using intradialytic systolic blood pressure variability (SBPV) and diastolic blood pressure variability (DBPV) as the dependent variables, and age, dialysis age and cardiac functional indices as the independent variables. Results A total of 111 MHD patients were recruited in this study. The intradialytic SBPV was positively correlated with patient age (r=0.332, P=0.000), ultrafiltration volume (r=0.261,P=0.049) and iPTH (r=0.375, P=0.003), and was negatively correlated with creatinine level (r=- 0.212,P=0.013). The intradialytic DBPV was positively correlated with end-diastolic left ventricle mass index (LVMI) (r= 0.199, P=0.040). The intradialytic SBPV was positively correlated with age (t= 2.911, P=0.004) after the adjustment of ultrafiltration volume, iPTH and creatinine. Conclusion The age of MHD patients was an independent risk factor for intradialytic SBPV, and the intradialytic DBPV influenced the end- diastolic left ventricle mass index in these patients.