中国血液净化

中国血液净化 ›› 2020, Vol. 19 ›› Issue (08): 554-558.doi: 10.3969/j.issn.1671-4091.2020.08.013

• 血管通路 • 上一篇    下一篇

中性粒细胞与淋巴细胞比值对动静脉内瘘经皮腔内血管成形术后通畅率的影响

黎淮1,翟亚玲2,袁亮1,郝丽1,闫军放1,张丹凤1,王德光1   

  1. 1安徽医科大学第二附属医院肾内科
    2郑州大学第一附属医院肾内科肾脏病研究所

  • 收稿日期:2020-03-16 修回日期:2020-06-15 出版日期:2020-08-12 发布日期:2020-08-12
  • 通讯作者: 王德光 wangdeguang@vip.163.com E-mail:wangdeguang@vip.163.com
  • 基金资助:

    国家自然科学青年基金项目(81600555)；

    中国博士后科学基金面上项目(2018M640684)；

    安徽省公益性技术应用研究联动计划项目(1604f0804021)

Effect of the neutrophil/lymphocyte ratio on patency rate of autologous arteriovenous fistulas after PTA

  1. 1Department of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China;  2Department of Nephrology, Renal Research Institute of Zhengzhou University, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:2020-03-16 Revised:2020-06-15 Online:2020-08-12 Published:2020-08-12

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摘要： 【摘要】目的观察中性粒细胞与淋巴细胞比值(neutrophil-lymphocyte ratio，NLR)对自体动静脉内瘘(autologous arteriovenous fistulas，AVF)狭窄经皮腔内血管成形术(percutaneous transluminal angioplasty，PTA)术后通畅率的影响。方法纳入2018 年6 月～2019 年7 月在安徽医科大学第二附属医院肾内科成功行PTA 术患者84 例，收集临床和随访资料。根据术前NLR 水平分为高NLR 组和低NLR 组，对比2 组基线资料，采用Log-rank 检验分析2 组间通畅率，使用COX 多因素回归分析影响PTA 术后通畅率的因素。结果男47 例，女37 例，平均随访时间(263.51±120.41)d。高NLR 组较低NLR 组术后再狭窄率高(χ 2=7.683，P=0.006)，高NLR 组血镁水平较低(t=2.486,P=0.015)，高NLR 组AVF 通畅率低于低NLR 组(Log Rank检验，χ2=7.885，P=0.005)。结论高NLR 是影响PTA 术后AVF 通畅率的独立危险因素。

关键词: 中性粒细胞与淋巴细胞比值, 动静脉内瘘, 经皮腔内血管成形术, 通畅率

Abstract: 【Abstract】Objective To investigate the effect of neutrophil/lymphocyte ratio (NLR) on patency of autologous arteriovenous fistulas (AVF) after percutaneous transluminal angioplasty (PTA). Methods This study consisted of 84 patients with successful PTA treated in the Department of Nephrology, the Second Hospital of Anhui Medical University between June 2018 and July 2019. Their clinical data and follow-up information were recruited. Patients were divided into two groups according to the level of NLR before PTA: high NLR group (n=42) and low NLR group (n=42). Survival analyses and log-rank test were used to compare the patency rate between the two groups. Multivariate Cox regression was used to analyze the interference factors for patency rate. Results There were 47 males and 37 females. The average follow- up time was 263.51±120.41 days. The rEstenosis rate was significantly higher in high NLR group compared to low NLR group (χ2=7.683, P=0.006). Serum magnesium was lower in high NLR group (t=2.486, P=0.015). The patency of AVF was significantly lower in high NLR group than in low NLR group (log rank test: χ2=7.885, P=0.005). Conclusion Higher NLR is an independent risk factor for the patency of AVF after PTA.

Key words: Neutrophil/Lymphocyte ratio, Autologous arteriovenous fistula, Percutaneous transluminal angioplasty, Patency rate

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