中国血液净化

中国血液净化 ›› 2021, Vol. 20 ›› Issue (01): 43-46.doi: 10.3969/j.issn.1671-4091.2021.01.10

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维持性血液透析患者皮肤瘙痒相关机制的研究进展

王颖1,毕慧欣1   

  1. 1桂林医学院附属医院肾内科
  • 收稿日期:2020-07-20 修回日期:2020-10-21 出版日期:2021-01-12 发布日期:2021-01-07
  • 通讯作者: 毕慧欣 269882436@qq.com E-mail:269882436@qq.com
  • 基金资助:
    广西壮族自治区中医药自筹经费科研课题（GZZC2019141）

Recent progresses in the pathogenesis of pruritus in maintenance hemodialysis patients

  1. 1Department of Nephrology, the Affiliated Hospital of Guilin Medical College, Guilin 541001, China
  • Received:2020-07-20 Revised:2020-10-21 Online:2021-01-12 Published:2021-01-07

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摘要： 【摘要】皮肤瘙痒是维持性血液透析的终末期肾脏疾病患者的常见问题，不同程度影响着患者的生活质量，引起焦虑、抑郁、睡眠障碍等，并且与慢性血液透析患者预后不良相关。虽然目前治疗方法有很多种，但发病机制较为复杂，疗效有限。本文从皮肤干燥、免疫炎症假说、组胺、二价离子、阿片样物质假说、甲状旁腺激素、周围神经病变、透析充分性及方式、糖基化假说分别阐述维持性血液透析患者皮肤瘙痒的相关发病机制。

关键词: 维持性血液透析, 皮肤瘙痒, 发病机制

Abstract: 【Abstract】skin pruritus is a common symptom in end-stage renal disease patients undergoing maintenance hemodialysis (MHD). Pruritus affects the quality of life, causes anxiety, depression, sleep disorders, and unfavorable prognosis of the patients. Although many kinds of treatment can be used clinically, the curative effect is limited. The pathogenesis of pruritus is complicated. This paper expounds the pathogenesis of skin pruritus in MHD patients from the perspectives of dry skin, immune inflammation hypothesis, histamine, bivalent ions, opioid hypothesis, parathyroid hormone, peripheral neuropathy, dialysis adequacy and mode, and glycosylation hypothesis.

Key words: Maintenance hemodialysis, Pruritus, Pathogenesis

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