中国血液净化

中国血液净化 ›› 2021, Vol. 20 ›› Issue (04): 248-253.doi: 10.3969/j.issn.1671-4091.2021.04.008

• 临床研究 • 上一篇    下一篇

血清生长分化因子-15 水平在不同类型肾脏疾病患者的差异及相关性分析

赵雪1,2,于澈1,王荣1   

  1. 1山东第一医科大学附属省立医院肾内科
    2山东大学齐鲁医学院临床医学专业
  • 收稿日期:2020-10-19 修回日期:2021-01-30 出版日期:2021-04-12 发布日期:2021-04-12
  • 通讯作者: 于澈 yuchesdu@hotmail.com E-mail:mzzsqywx@163.com
  • 基金资助:
    国家自然科学基金(81770723)

Difference and correlation analysis of serum GDF-15 level in patients with different types of nephropathy

  1. 1Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan 250021, China; 2Department of Clinical Medicine, Cheeloo Medical College, Shandong University, Jinan 250012, China
  • Received:2020-10-19 Revised:2021-01-30 Online:2021-04-12 Published:2021-04-12
  • Contact: Che —Yu E-mail:mzzsqywx@163.com

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摘要： 【摘要】目的探讨不同类型肾病患者血清生长分化因子-15(growth differentiation factor-15, GDF-15)的表达水平及与其他肾功能相关临床指标的相关性。方法选取山东第一医科大学附属省立医院2019 年12 月～2020 年8 月健康查体中心体检者15 例为对照组，肾内科、血液科不同类型肾病患者122例，ELISA 法测定其血清GDF-15 水平，收集临床资料及实验室指标(如血清白蛋白、血糖、血肌酐、肾小球滤过率、游离轻链等)，分析GDF-15 与各指标间关系。结果糖尿病肾病患者GDF-15 水平分别高于正常对照组(t=6.522,P＜0.001)、IgA 肾病组(t=4.322,P=0.004)、狼疮肾炎组(t=3.884,P=0.001)；多发性骨髓瘤(multiple myeloma,MM) 患者GDF- 15 水平高于正常对照组(t=5.678, P＜0.001)、IgA 肾病组(t=4.532, P=0.004)以及狼疮肾炎组(t=4.244, P=0.008)。年龄(r=0.395, P＜0.001)、免疫固定电泳异常(r=0.251, P=0.003)、血糖(r=0.205, P=0.016)、C 反应蛋白(C- reactive protein, CRP) (r=0.178, P= 0.038)、游离轻链比值(r=0.324, P＜0.001)以及MM(r =0.225，P =0.008)均与GDF-15 浓度呈正相关。线性回归分析示：GDF- 15 浓度与年龄(β=0.395, p＜0.001)、CRP 升高(β=0.175, P=0.040)、MM(β =0.192, P=0.025)、免疫固定电泳异常(β=0.251, P=0.003)、游离轻链比值异常(β=0.299, P＜0.001)相关。结论GDF-15水平在不同类型肾脏疾病表达有一定差异，且与年龄、血糖、CRP、MM、游离轻链比值、免疫固定电泳等相关，是反应肾脏损伤程度的重要的临床指标。

关键词: 生长分化因子-15, 不同肾脏疾病, 免疫固定电泳, 游离轻链

Abstract: 【Abstract】Objective To investigate the serum growth differentiation factor-15 (GDF-15) level in patients with different types of renal diseases and its correlation with renal function. Methods We recruited 122 patients with different types of nephropathy treated in the Department of Nephrology, Shandong Provincial Hospital from December 2019 to August 2020 in this study, and 15 healthy people from physical examination center as the control group. Serum GDF-15 was detected by ELISA. Clinical data and laboratory parameters were collected, and analyzed in association with serum GDF-15 and other factors. Results Serum GDF-15
was significantly higher in patients with diabetic nephropathy than that in control group (t=6.522, P＜0.001), IgA nephropathy (t=4.322, P=0.004) and lupus nephritis patients (t=3.884, P=0.001). Serum GDF-15 was significantly higher in multiple myeloma patients than in control group (t=5.678, P＜0.001), IgA nephropathy (t=4.532, P=0.004) and lupus nephritis patients (t=4.244, P=0.008). Age (r=0.395, P<0.001), abnormal immunofixation electrophoresis (r=0.251, P=0.003), blood glucose (r=0.205, P= 0.016), CRP (r=0.178, P=0.038), free light chain ratio (r=0.324, P<0.001), and MM (r=0.225, P=0.008) were positively correlated with serum GDF-15 level. Linear regression analysis showed that serum GDF-15 level was significantly associated with age (β= 0.395, P<0.001), elevated CRP (β=0.175, P=0.040), MM (β=0.192, P=0.025), abnormal immunofixation electrophoresis (β=0.251, P=0.003), and abnormal free light chain ratio (β=0.299, P<0.001). Conclusions Serum GDF-15 level varied in different renal diseases and was correlated with age, blood glucose, CRP,MM, free light chain ratio and abnormal immunofixation electrophoresis. Serum GDF-15 level is a useful index reflecting the extent of kidney injury.

Key words: Growth differentiation factor- 15, Renal diseases, Immunofixation electrophoresis, Free light chain

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