中国血液净化

中国血液净化 ›› 2021, Vol. 20 ›› Issue (04): 273-276.doi: 10.3969/j.issn.1671-4091.2021.04.013

• 综述 • 上一篇    下一篇

膜铁转运蛋白在肾性贫血中的研究进展

席悦1,杜玄一1   

  1. 1哈尔滨医科大学附属第二医院肾内科
  • 收稿日期:2020-10-19 修回日期:2020-12-31 出版日期:2021-04-12 发布日期:2021-04-12
  • 通讯作者: 杜玄一 dxy_shennei@126.com E-mail:dxy_shennei@126.com

Research progress in ferroportin in renal anemia

  1. 1Department of Nephrology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
  • Received:2020-10-19 Revised:2020-12-31 Online:2021-04-12 Published:2021-04-12
  • Contact: Xuan yiDU E-mail:dxy_shennei@126.com

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摘要： 【摘要】膜铁转运蛋白(ferroportin,Fpn)是目前唯一的铁转出蛋白，它在控制饮食中铁的吸收，巨噬细胞和其他细胞中铁的排出中起着重要作用。铁是机体不可缺少的物质，参与血红蛋白合成。一旦Fpn的表达发生障碍，必定会导致铁代谢紊乱，从而引起多种疾病的发生发展。当然也可引起红细胞生成减少，甚至引起和加重慢性肾脏病(chronic kidney disease，CKD)贫血。因此，Fpn 在机体铁代谢中发挥着重要作用。本文就Fpn在肾性贫血中的研究进展作一综述。

关键词: 膜铁转运蛋白, 慢性肾脏病, 贫血, 铁代谢

Abstract: 【Abstract】Ferroportin (Fpn) is currently the unique iron export transfer protein, playing an important role in controlling the absorption of iron in diet and the excretion of iron from macrophages and other cells. Iron is an indispensable element in the body, participating in hemoglobin synthesis. If the expression of Fpn is disturbed, iron metabolism disorder and many related diseases will inevitably occur, red blood cell production is decreased, and chronic kidney disease (CKD) anemia is aggravated. This article reviews the research progress in Fpn, an important protein in the regulation of iron metabolism, in renal anemia.

Key words: Ferroportin, Chronic kidney disease, Anemia, Iron metabolism

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