中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (03): 191-193.doi: 10.3969/j.issn.1671-4091.2022.03.011

• 综述 • 上一篇    下一篇

血液净化清除硫酸吲哚酚的研究进展

陈爽1,2,白风霞1,2,吴祯1,2,张海松1   

  1. 1河北大学附属医院肾内科
    2河北大学临床医学院

  • 收稿日期:2021-10-08 修回日期:2021-11-02 出版日期:2022-03-12 发布日期:2022-03-16
  • 通讯作者: 张海松 hedafuyuan-zhs@126.com E-mail:hedafuyuan-zhs@126.com
  • 基金资助:
    河北省自然科学基金资助项目(H2018201289)

Research progress in the removal of indoxyl sulfate by blood purification

  1. 1Department of Nephrology, the Affiliated Hospital of Hebei University, Baoding 071000, China; 2School of Clinical Medicine, Hebei University, Baoding 071000, China
  • Received:2021-10-08 Revised:2021-11-02 Online:2022-03-12 Published:2022-03-16

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摘要： 【摘要】硫酸吲哚酚(indoxyl sulfate，IS)是一种典型的尿毒症毒素，由肠道菌群分解色氨酸后经过一系列代谢形成，与血浆白蛋白结合率高达90%以上。在慢性肾脏病(chronic kidney disease,CKD)中,由于肾功能受损，导致IS 不能有效经肾小管分泌排出体外而蓄积。越来越多的证据表明，IS 在CKD并发症的发生发展中起关键作用，且与预后相关。因此如何有效清除IS 显得尤为重要，现对近几年围绕血液净化清除IS的研究做一总结。

关键词: 硫酸吲哚酚, 慢性肾脏病, 血液净化

Abstract: 【Abstract】Indoxyl sulfate (IS), a typical uremia toxin, is the product of tryptophan decomposed by intestinal flora and then by a series of metabolic processes. Its binding rate with plasma albumin was more than 90%. In chronic kidney disease (CKD), IS cannot be effectively secreted and excreted through the impaired renal tubules. More evidences have shown that IS plays a key role in the presence and development of uremic complications and is also related to the prognosis of uremic patients. Therefore, the clearance of IS is particularly important. Here we summarize the recent advances in the clearance of IS by blood purification.

Key words: Indoxyl sulfate, Chronic kidney disease, Blood purification

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