中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (03): 194-197.doi: 10.3969/j.issn.1671-4091.2022.03.012

• 综述 • 上一篇    下一篇

钙蛋白颗粒与慢性肾脏病血管钙化相关性的研究进展

刘义琴1,欧三桃1   

  1. 1西南医科大学附属医院肾病内科，四川省肾脏病临床医学研究中心
  • 收稿日期:2021-09-16 修回日期:2021-10-16 出版日期:2022-03-12 发布日期:2022-03-16
  • 通讯作者: 欧三桃 ousantao@163.com E-mail:379868270@qq.com
  • 基金资助:
    四川省肾脏疾病临床医学研究中心2020年开放课题重点项目(2019YFS0537-3)

Research progress in the relationship between calciprotein particles and vascular calcification in chronic kidney disease patients

  1. 1Department of Nephrology, the Affiliated Hospital of Southwest Medical University, Sichuan Clinical Research Center for Nephrology, Luzhou, Sichuan 646000, China
  • Received:2021-09-16 Revised:2021-10-16 Online:2022-03-12 Published:2022-03-16
  • Contact: San TaoOU E-mail:379868270@qq.com

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摘要： 【摘要】血清钙蛋白颗粒(calciproteinparticles,CPPs)是一种胶体纳米颗粒，是新近发现的一种慢性肾脏病矿物质和骨代谢异常(chronic kidney disease-mineral and bone disorder,CKD-MBD)的生物标志物,其在慢性肾脏病血管钙化(vascular calcification,VC)中的作用越来越受到人们的重视。本文主要就CPPs 的基本结构及其生物学活性，CPPs 与血管钙化的密切关系做一综述，为慢性肾脏病血管钙化防治提供新的诊断标记物和治疗靶点。

关键词: 钙蛋白颗粒, 血管钙化, 慢性肾脏病

Abstract: 【Abstract】Serum calciprotein particles (CPPs) are present in the form of colloidal nanoparticles in serum and have become a novel biological marker for chronic kidney disease-mineral and bone disorder (CKDMBD). CPPS are now intrigued by its involvement in the pathogenesis of vascular calcification in CKD patients. This article reviews the basic structure and biological activities of CPPs as well as the relationship between CPPs and vascular calcification, so as to provide a new diagnostic marker and therapeutic target for vascular calcification in CKD patients.

Key words: Calciprotein particles, Vascular calcification, Chronic kidney disease

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