中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (04): 235-239.doi: 10.3969/j.issn.1671-4091.2022.04.003

• 临床研究 • 上一篇    下一篇

NLRP3/IL-1β 信号通路活化与维持性血液透析患者血高密度脂蛋白胆固醇降低相关

邱杰山1,暨利军1,王燕翔1,徐志勇1, 张婷玉1,郑峰1,李飞飞1,何强2   

  1. 1仙居县人民医院(浙江省人民医院浙东南院区)肾脏内科何强名医工作室
    2浙江省人民医院肾脏内科
  • 收稿日期:2021-09-16 修回日期:2022-01-19 出版日期:2022-04-12 发布日期:2022-04-07
  • 通讯作者: 邱杰山 qiujieshanww@126.com. E-mail:qiujieshanww@126.com
  • 基金资助:
    仙居县人民医院青年创新人才支持计划(21yja02)；台州市科技局科研项目(1702KY69)；武威市科技计划项目(ww180262)

Activation of NLRP3/IL-1β signaling pathway is associated with reduction of HDL-C in patients with maintenance hemodialysis

  1. 1Department of Nephrology, Xianju People’s Hospital, East and South district of Zhejiang Provincial People's Hospital, Xianju 317300, China;  2Zhejiang Provincial People's Hospital, Hangzhou 317000, China
  • Received:2021-09-16 Revised:2022-01-19 Online:2022-04-12 Published:2022-04-07

PDF

209

摘要： 【摘要】目的探讨维持性血液透析(maintenance hemodialysis,MHD)患者Nod 样受体蛋白3/白细胞介素-1β(Nod-like receptor protein 3/interleukin 1β,NLRP3/IL-1β)信号通路活化与高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平及动脉粥样硬化(atherosclerosis, AS)发生的关系。方法行MHD 治疗的患者83 例为研究组，20 例健康人为对照组，检测生化指标、HDL-C、血白细胞介素(IL)-1β、IL-18 及外周血单核细胞NLRP3mRNA；测定颈动脉内膜中层厚度(intimamedia thickness,IMT)。比较2 组间上述指标的差异；分析HDL-C及颈动脉IMT与NLRP3mRNA、IL-1β及IL-18的相关性；明确影响MHD患者HDL-C水平及颈动脉IMT的危险因素。结果研究组MHD患者HDL-C低于对照组(t=-7.048, P<0.001)，颈动脉IMT值大于对照组(t=2.634, P<0.001)；血HDL-C与NLRP3mRNA ( r=-0.682, P<0.001)、IL-1β(r=-0.537, P<0.001)及IL-18(r=-0.426, P<0.001)呈负相关；颈动脉IMT与NLRP3mRNA (r= 0.521，P＜0.001)、IL-1β(r=0.569，P＜0.001)及IL-18(r=0.674，P＜0.001)成正相关；NLRP3mRNA 活化是HDL-C 降低的危险因素(B=-0.390，p＜0.001)，而NLRP3mRNA、IL-18 活化(B=0.069、0.002，均P＜0.001)及HDL- C 降低(B=- 0.106，P＜0.001)是MHD 患者颈动脉IMT 增厚的危险因素。结论NLRP3/IL-1β 信号通路参与了MHD患者血HDL-C 水平降低及颈动脉IMT 增厚。

关键词: Nod 样受体蛋白3, 白细胞介素1β, 白细胞介素18, 血液透析, 高密度脂蛋白胆固醇-C

Abstract: 【Abstract】Objective To investigate the relationship between of Nod-like receptor protein 3/interleukin-1β (NLRP3/IL-1β) signaling pathway activation and blood high-density lipoprotein cholesterol (HDL-C) level and atherosclerosis (AS) in patients with maintenance hemodialysis (MHD). Methods A total of 83 patients who underwent MHD were collected as the study group, and 20 healthy individuals as the control group. Their biochemical indexes, HDL-C, serum IL-1β, interleukin-18 (IL-18) and NLRP3 mRNA were assayed, and the carotid intima-media thickness (IMT) was measured. The differences of these results were compared
between the two groups. The correlations between HDL-C and NLRP3 mRNA, carotid artery IMT and NLRP3 mRNA, and IL-1β and IL-18 were analyzed respectively. The risk factors affecting HDL-C level and carotid IMT in MHD patients were explored. Results HDL-C level was lower in MHD patients than in the control group (t=-7.048，P<0.001), while carotid IMT value was higher in MHD patients than in the control group (t=2.634，P<0.001). HDL- C was negatively correlated with NLRP3 mRNA (r=- 0.682, P<0.001), IL- 1β (r=-0.537, P<0.01) and IL-18 (r=-0.426, P<0.01). Carotid artery IMT was positively correlated with NLRP3 mRNA (r=0.521, P<0.001), IL-1β (r=0.569, P<0.001) and IL-18 (r=0.674, P<0.001). Hence, the activation of NLRP3 mRNA was the risk factor for low HDL-C level (B=-0.390, P<0.001), while the activation of NLRP3 mRNA (B=0.069, P<0.001) and IL-18 signals (B=0.002, P< 0.001) and the decrease of HDL-C (B=-0.106, P<0.001) were the risk factors for the increase of carotid IMT in MHD patients. Conclusion NLRP3/IL-1β signal pathway is involved in the decrease of blood HDL-C level and the thickening of carotid artery IMT in
MHD patients.

Key words: Nod?like receptor protein 3, Interleukin 1β, Interleukin 18, Maintenance hemodialysis, High density lipoprotein cholesterol

中图分类号: