中国血液净化

中国血液净化 ›› 2023, Vol. 22 ›› Issue (03): 206-209.doi: 10.3969/j.issn.1671-4091.2023.03.011

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血清代谢组学与维持性血液透析患者自体动静脉内瘘狭窄的关系

廖 露    邹丽婷    付梦茹    鄢  艳    肖  俊   

  1. 330006 南昌，1南昌大学第一附属医院肾内科
  • 收稿日期:2022-09-22 修回日期:2022-12-27 出版日期:2023-03-12 发布日期:2023-03-03
  • 通讯作者: 肖 俊 E-mail:xjfish227@163.com
  • 基金资助:
    国家自然科学基金地区项目(82060148)

Relationship between serum metabolomics and stenosis in autologous arteriovenous fistula in maintenance hemodialysis patients

LIAO Lu, ZOU Li-ting, FU Meng-ru, YAN yan, XIAO Jun   

  1. Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • Received:2022-09-22 Revised:2022-12-27 Online:2023-03-12 Published:2023-03-03
  • Contact: 南昌，1南昌大学第一附属医院肾内科 E-mail:xjfish227@163.com

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摘要： 随着慢性肾脏病（chronic kidney disease, CKD）5期的发病率不断增加，维持性血液透析(hematodialysis, HD)的患者人数日益增多。自体动静脉内瘘(Arteriovenous fistula, AVF)是HD患者长期血管通路的首选方式。AVF狭窄是HD患者AVF失功的主要原因，其机制尚未完全阐明。CKD5期患者常因血液代谢产物的种类及浓度发生改变而引起各种相关并发症，代谢组学技术的应用揭示了CKD患者体内存在的各种代谢紊乱。本文通过分析CKD患者血液代谢组学异常与AVF狭窄的相关性，希望为阐明AVF狭窄的机制及防治AVF狭窄提供新的思路。

关键词: 慢性肾脏病5期, 自体动静脉内瘘狭窄, 代谢组学, 血液透析

Abstract: With the increasing incidence of chronic kidney disease (CKD) stage 5, the number of patients with maintenance hemodialysis (HD) is increasing. Autogenous Arteriovenous fistula (AVF) is the preferred method for long-term vascular access in HD patients. AVF stenosis is the main cause of AVF dysfunction in HD patients, and its mechanism has not been fully elucidated. CKD5 patients often cause various related complications due to changes in the types and concentrations of blood metabolites. The application of metabolomics technology has revealed various metabolic disorders in CKD patients. This article analyzes the correlation between abnormal blood metabolomics and AVF stenosis in CKD patients, hoping to provide new ideas for elucidating the mechanism of AVF stenosis and prevention and treatment of AVF stenosis

Key words: Chronic kidney disease at stage 5, Autogenous arteriovenous fistula stenosis, Metabolomics, Hemodialysis

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