中国血液净化

中国血液净化 ›› 2024, Vol. 23 ›› Issue (06): 406-409.doi: 10.3969/j.issn.1671-4091.2024.06.002

• 临床研究 • 上一篇    下一篇

中性pH、低GDPs腹膜透析液对腹膜透析患者腹膜透析液CA125的影响

贾玉霞     孙永贺     魏小飞     牛永勤     张 坤   

  1. 236600 阜阳，1安徽中医药大学附属太和中医院肾病科
  • 收稿日期:2024-01-24 修回日期:2024-03-29 出版日期:2024-06-12 发布日期:2024-06-12
  • 通讯作者: 张坤 E-mail:jiayuxia1214@163.com
  • 基金资助:
    236600 阜阳，1安徽中医药大学附属太和中医院肾病科

The Effect of peritoneal dialysis fluid with neutral pH and low GDPs on CA125 level in peritoneal dialysispatients

JIA Yu-xia,  SUN Yong-he,  WEI Xiao-fei,  NIU Yong-qin, ZHANG Kun   

  1. Department of Nephrology，Taihe Hospital of Traditional Chinese Medicine of Anhui University of Traditional Chinese Medicine, Fuyang 236600, China 
  • Received:2024-01-24 Revised:2024-03-29 Online:2024-06-12 Published:2024-06-12
  • Contact: 236600 阜阳，1安徽中医药大学附属太和中医院肾病科 E-mail:jiayuxia1214@163.com

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摘要： 目的  观察中性pH-低葡萄糖降解产物(glucose degradation products，GDPs)腹膜透析液对腹膜透析(peritoneal dialysis，PD)患者糖类抗原125(cancer antigen 125，CA125)的影响，以评估其效果。 方法 以持续非卧床PD患者为研究对象，初始使用标准钙腹膜透析液透析，后使用中性pH、低GDPs腹膜透析液持续透析6个月。将使用标准钙腹膜透析液时设为A组，使用中性pH、低GDPs腹膜透析液6个月后设为B组，观察患者透出液CA125及血清CA125浓度，超滤量及是否具有透析痛。 结果  共纳入44例PD患者，其中男性24例，女性20例。与A组相比，B组患者透出液CA125(t=2.266，P=0.029)、血清CA125(t=2.575，P=0.014)、腹膜透析超滤量(Z=5.052，P＜0.001)较高，血红蛋白(t=2.208，P=0.033)、钙离子(t=2.843，P=0.007)、磷离子(t=2.094，P=0.042)较低。 结论 腹膜透析患者使用中性pH、低GDPs腹膜透析液可以增加患者透出液CA125水平，间接提示腹膜间皮细胞损伤减少。 

关键词: 中性pH-低葡萄糖降解产物腹膜透析液, 腹膜透析, 糖类抗原125, 间质细胞

Abstract: Objective  To evaluate the effect of neutral pH and low glucose degradation products (glucose degradation products, GDPs) on CA125 in peritoneal dialysis (peritoneal dialysis,PD) patients. Methods Continuous ambulatory peritoneal dialysis  patients were enrolled. These patients were initially dialyzed with standard calcium peritoneal dialysis solution, followed by 6 months of dialysis with neutral pH and low GDPs peritoneal dialysis solution. Compare the concentrations of CA125 in the exudate and serum, ultrafiltration volume, and whether there is dialysis pain of these patients when using standard PD fluid (group A) and after using neutral pH and low GDPs PD fluid (group B).  Results  A total of 44 PD patients were included, including 24 males and 20 females. Compared with group A, group B had higher effluent CA125 (t=2.266, P=0.029), serum CA125 (t=2.575, P=0.014), peritoneal dialysis ultrafiltration (Z=5.052, P <0.001), and lower hemoglobin (t=2.208, P=0.033), calcium (t=2.843, P=0.007), and phosphorus (t=2.094, P=0.042).  Conclusion  The peritoneal dialysis fluid with neutral pH, low GDPs can increase the CA125 level in peritoneal dialysis patients, which indirectly indicates the reduced damage of peritoneal mesothelial cells.

Key words: Neutral pH-low glucose degradation product peritoneal dialysis fluid；Peritoneal dialysis, cancer antigen 125, Interstitial cells

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